Most Read Articles
05 Feb 2021

Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.

Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Roshini Claire Anthony, 26 Feb 2021

Critical or severe COVID-19 disease could raise the risk of negative perinatal outcomes in pregnant women, according to an observational study from the US.

Stephen Padilla, 22 Feb 2021
Treatment with intravenous (IV) dexamethasone for 10 days significantly reduces duration of mechanical ventilation at 28 days and 60-day mortality in patients with established moderate-to-severe acute respiratory disease syndrome (ARDS) compared with no dexamethasone, results of the DEXA-ARDS trial have shown.

Belly fat may lead to vertebral fractures

22 Feb 2021

Abdominal obesity contributes to a heightened risk of developing vertebral fracture (VF) in men, a study reports. In women, a large waist circumference (WC) confers a risk increase.

The analysis included 352,095 individuals who were representative of the Korean National Health Insurance System. Participants were aged ≥40 years who underwent health checkups between 2009 and 2012. Abdominal obesity was defined according to the Asian-specific WC cutoff, that is ≥90 cm in men and ≥85 cm in women.

Over 5.5 years of follow-up, a total of 2,030 and 4,968 new cases of VF were recorded in men and women, respectively. Multivariable Cox proportional hazard regression analysis revealed that men with versus without abdominal obesity had an elevated risk of VF (hazard ratio [HR], 1.11, 95 percent confidence interval [CI], 1.01–1.23).

In women, on the other hand, the risk of VF increased accordingly in higher WC groups (ptrend<0.001). Relative to a WC of 80.0–84.9 cm, a WC 85.0–89.9 cm was associated with a 12-percent higher VF risk (HR, 1.12, 95 percent CI, 1.02–1.22), 90.0–94.9 cm with a 19-percent elevation (HR, 1.19, 95 percent CI, 1.08–1.32), and ≥95.0 cm with a 27-percent increase (HR, 1.27, 95 percent CI, 1.12–1.43). Meanwhile, WC <75.0 cm showed a protective association (HR, 0.81, 95 percent CI, 0.75–0.88). The estimates persisted despite stratification by age in women.

In light of the findings, trimming the WC and controlling abdominal obesity may be beneficial in reducing future VF risk.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Endocrinology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
05 Feb 2021

Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.

Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Roshini Claire Anthony, 26 Feb 2021

Critical or severe COVID-19 disease could raise the risk of negative perinatal outcomes in pregnant women, according to an observational study from the US.

Stephen Padilla, 22 Feb 2021
Treatment with intravenous (IV) dexamethasone for 10 days significantly reduces duration of mechanical ventilation at 28 days and 60-day mortality in patients with established moderate-to-severe acute respiratory disease syndrome (ARDS) compared with no dexamethasone, results of the DEXA-ARDS trial have shown.