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01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
18 Feb 2021
Treatment with tanezumab appears to relieve pain and improve physical function in patients with hip or knee osteoarthritis (OA), but may lead to dose-dependent increase in joint safety events as compared with nonsteroidal anti-inflammatory drug (NSAID), according to the results of a phase III safety trial.
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Belly fat may lead to vertebral fractures

3 days ago

Abdominal obesity contributes to a heightened risk of developing vertebral fracture (VF) in men, a study reports. In women, a large waist circumference (WC) confers a risk increase.

The analysis included 352,095 individuals who were representative of the Korean National Health Insurance System. Participants were aged ≥40 years who underwent health checkups between 2009 and 2012. Abdominal obesity was defined according to the Asian-specific WC cutoff, that is ≥90 cm in men and ≥85 cm in women.

Over 5.5 years of follow-up, a total of 2,030 and 4,968 new cases of VF were recorded in men and women, respectively. Multivariable Cox proportional hazard regression analysis revealed that men with versus without abdominal obesity had an elevated risk of VF (hazard ratio [HR], 1.11, 95 percent confidence interval [CI], 1.01–1.23).

In women, on the other hand, the risk of VF increased accordingly in higher WC groups (ptrend<0.001). Relative to a WC of 80.0–84.9 cm, a WC 85.0–89.9 cm was associated with a 12-percent higher VF risk (HR, 1.12, 95 percent CI, 1.02–1.22), 90.0–94.9 cm with a 19-percent elevation (HR, 1.19, 95 percent CI, 1.08–1.32), and ≥95.0 cm with a 27-percent increase (HR, 1.27, 95 percent CI, 1.12–1.43). Meanwhile, WC <75.0 cm showed a protective association (HR, 0.81, 95 percent CI, 0.75–0.88). The estimates persisted despite stratification by age in women.

In light of the findings, trimming the WC and controlling abdominal obesity may be beneficial in reducing future VF risk.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
18 Feb 2021
Treatment with tanezumab appears to relieve pain and improve physical function in patients with hip or knee osteoarthritis (OA), but may lead to dose-dependent increase in joint safety events as compared with nonsteroidal anti-inflammatory drug (NSAID), according to the results of a phase III safety trial.
05 Feb 2021

Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.