Most Read Articles
Rachel Soon, 12 Dec 2018

MIMS Pharmacist speaks to Cpt. Manvikram Singh Gill, military pharmacist with the Royal Medical and Dental Corps (RMDC) of the Malaysian Armed Forces (MAF),about his work at the Rohingya refugee camp in Cox's Bazar, Bangladesh.

Ms Penny Wong Pei Nee, 12 Jul 2018
Antibiotics, also known as antibacterials, are a group of medications that either destroy the infecting bacteria or slow down their growth.
Elaine Soliven, 30 Jun 2020
Treatment with Lactobacillus crispatus CTV-05 (Lactin-V) significantly reduces the incidence of bacterial vaginosis recurrence in women who were previously treated with vaginal metronidazole, according to a recent study.
Jairia Dela Cruz, 20 May 2020
Concomitant use of fimasartan and rosuvastatin in patients with hypertension and dyslipidaemia does not appear to be synergistic in increasing concurrent control rate of the diseases, although either drug is effective against the target disease, according to a study.

Bedaquiline, delamanid both effective against multidrug-resistant tuberculosis

23 Apr 2020

The new drugs bedaquiline and delamanid appear to be safe and effective in patients with tuberculosis resistant to multiple treatments, according to the results of a study conducted in South Korea.

Researchers looked at 318 patients, among whom 282 (88.7 percent) were treated with the two drugs (bedaquiline, n=107; delamanid, n=108; both concurrently or sequentially, n=67). They evaluated culture conversion rates, interim treatment outcomes at 12 months, and predictors of unfavourable outcomes.

The mean age of the population was 49.3 years, and 197 patients (69.9 percent) were male. Three patients were HIV seropositive, and 151 (53.5 percent) were resistant to quinolone.

The culture conversion rates were 57.4 percent (81/141) at 2 months and 89.4 percent (126/141) at 6 months. The 12-month outcome was favourable in the majority of the population (239/282; 84.8 percent).

Differences in the culture conversion rate or in interim treatment outcomes were not statistically significant according to drug susceptibility test patterns or new drugs used. Further analysis revealed that older age (>60 years) and lower body mass index (<18.5 kg/m2) were significantly associated with unfavourable outcomes at 12 months.

Adverse drug reactions rarely occurred on either bedaquiline or delamanid.

The present data show satisfactory interim treatment results in patients with multidrug-resistant tuberculosis, with no significant differences between the two drugs, the researchers said.

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Most Read Articles
Rachel Soon, 12 Dec 2018

MIMS Pharmacist speaks to Cpt. Manvikram Singh Gill, military pharmacist with the Royal Medical and Dental Corps (RMDC) of the Malaysian Armed Forces (MAF),about his work at the Rohingya refugee camp in Cox's Bazar, Bangladesh.

Ms Penny Wong Pei Nee, 12 Jul 2018
Antibiotics, also known as antibacterials, are a group of medications that either destroy the infecting bacteria or slow down their growth.
Elaine Soliven, 30 Jun 2020
Treatment with Lactobacillus crispatus CTV-05 (Lactin-V) significantly reduces the incidence of bacterial vaginosis recurrence in women who were previously treated with vaginal metronidazole, according to a recent study.
Jairia Dela Cruz, 20 May 2020
Concomitant use of fimasartan and rosuvastatin in patients with hypertension and dyslipidaemia does not appear to be synergistic in increasing concurrent control rate of the diseases, although either drug is effective against the target disease, according to a study.