Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
3 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.

Barret’s oesophagus, PPI use do not pose increased fracture risk

03 Nov 2017

Barret’s oesophagus patients do not appear to be at greater risk of osteoporotic fractures compared with the general population, according to a study. Moreover, the use of proton pump inhibitors (PPI) does not contribute to an increased risk regardless of the duration of therapy or dosing strategy.

The study drew data from the Rochester Epidemiology Project resources and included 521 Barret’s oesophagus patients (median age 61 years; 76 percent male). The incidence rates of all and osteoporotic fractures in these patients were evaluated against the incident rates in an age- and gender-matched population in the Olmsted County.

Of the patients, 21.7 percent had fractures and 8.8 percent had osteoporotic fractures. The incidence of all fractures and osteoporotic fractures was comparable to that in the Olmsted population (standard incidence ratio [SIR] of all fractures, 1.09; 95 percent CI, 0.92 to 1.29: SIR of osteoporotic fractures, 1.05; 0.85 to 1.29).

PPI dose or duration of use was not related to osteoporotic fracture risk (hazard ratio, 0.87; 0.12 to 6.39). On Cox proportional analysis, older age, female gender and higher comorbidity index emerged as independent risk factors for osteoporotic fractures.

The present data suggest that Barret’s oesophagus patients who are on chronic PPI therapy are not at increased risk of developing subsequent fractures (from any aetiology or secondary to low bone mass) relative to the general population, researchers said.

Potential mechanisms by which PPI might affect skeletal integrity include altered bone remodelling, decreased intestinal calcium absorption and negative overall body calcium balance, all ultimately leading to increased fracture risk. [Current Drug Safety 2008;3:204-209; Am J Med 2005;118:778-781]

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
3 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.