Most Read Articles
Audrey Abella, 10 Oct 2017
The SYSADOA* chondroitin sulfate was as effective as the NSAID** celecoxib and superior to placebo in reducing pain and improving function for over 6 months in patients with symptomatic knee osteoarthritis (OA), according to the CONCEPT*** trial.
Pearl Toh, 10 May 2017
Celecoxib is preferred over naproxen when added to proton-pump inhibitor (PPI) for preventing recurrent upper gastrointestinal (GI) bleeding in patients at high risk of both GI and cardiovascular (CV) events, who require concomitant aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), according to the CONCERN* study.
11 Feb 2017
Nonsteroidal anti-inflammatory drugs (NSAIDs) provide potential therapeutic benefits for spinal pain, although the effect does not significantly differ from that provided by placebo, according to a meta-analysis.
06 Jan 2018
Celecoxib at approved dosages show similar or better cardiovascular, gastrointestinal, and renal safety profiles compared with ibuprofen and naproxen in the management of osteoarthritis and rheumatoid arthritis, a recent study has reported.

Baricitinib appears to be safe, effective in phase IIb study

03 Feb 2018
Many drugs result in successful laboratory tests but fewer than 12% entering clinical trials end up in pharmacies.

Baricitinib has shown consistent safety and tolerability up to 128 weeks, with no unexpected late signals, according to the results of a phase IIb study in rheumatoid arthritis (RA). In addition, clinical improvements during the 24-week blinded period persist during the open-label extension (OLE).

Treatment-emergent adverse events (AEs) occurred in 63 percent of patients in the 4-mg group and 67 percent in the 8-mg group. Furthermore, serious AE presented in 16 percent and 13 percent, infections in 35 percent and 40 percent, and serious infections in 5 percent and 3 percent of patients, respectively.

All baricitinib groups in the second OLE had similar or lower exposure-adjusted incidence rates for AE compared with the first OLE. There were no opportunistic infections, tuberculosis cases or lymphomas seen through week 128, but there was one death during the first OLE.

In addition, the proportions of patients in both OLE who achieved disease improvement at week 24 were either similar or greater at weeks 76 and 128.

To evaluate the safety and efficacy of baricitinib in RA patients up to 128 weeks, researchers enrolled eligible patients in an initial 52-week OLE following a 24-week blinded period. Patients administered 8-mg baricitinib once daily (QD; n=93) continued with that dose and all others received 4 mg QD (n=108).

Depending on researcher discretion, doses could be increased to 8 mg QD at week 28 or 32 when ≥6 tender and ≥6 swollen joints were present. Those who completed the first OLE were allowed to enter a second 52-week OLE and receive 4 mg QD irrespective of previous dose.

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Most Read Articles
Audrey Abella, 10 Oct 2017
The SYSADOA* chondroitin sulfate was as effective as the NSAID** celecoxib and superior to placebo in reducing pain and improving function for over 6 months in patients with symptomatic knee osteoarthritis (OA), according to the CONCEPT*** trial.
Pearl Toh, 10 May 2017
Celecoxib is preferred over naproxen when added to proton-pump inhibitor (PPI) for preventing recurrent upper gastrointestinal (GI) bleeding in patients at high risk of both GI and cardiovascular (CV) events, who require concomitant aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), according to the CONCERN* study.
11 Feb 2017
Nonsteroidal anti-inflammatory drugs (NSAIDs) provide potential therapeutic benefits for spinal pain, although the effect does not significantly differ from that provided by placebo, according to a meta-analysis.
06 Jan 2018
Celecoxib at approved dosages show similar or better cardiovascular, gastrointestinal, and renal safety profiles compared with ibuprofen and naproxen in the management of osteoarthritis and rheumatoid arthritis, a recent study has reported.