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Bariatric surgery reduces risk of all-cause death

28 Aug 2020

Patients who underwent bariatric surgery have considerably lower all-cause, cardiovascular, and cancer mortality, with the largest absolute effects seen in men and in those aged 55 years, according to a recent study.

“Mortality after bariatric surgery has been previously studied, but cohort selection bias, completeness of follow-up, and collection of confounders have limited the inference of results,” the authors said.

This population-based matched cohort study assessed the association between bariatric surgery and all-cause mortality in 13,679 patients who went through the procedure from January 2010 to December 2016 and in 13,679 matched nonsurgical individuals in Ontario, Canada.

The overall mortality rate after a median follow-up of 4.9 years was lower in the surgery group compared with the nonsurgery group (1.4 percent vs 2.5 percent), with a lower adjusted hazard ratio (HR) of overall all-cause mortality (HR, 0.68, 95 percent CI, 0.57–0.81).

Patients aged 55 years had a 3.3-percent (95 percent CI, 2.3–4.3 percent) absolute risk reduction, with a lower HR of mortality in the surgery group (HR, 0.53, 95 percent CI, 0.41–0.69). Although the relative effects observed were comparable across sex, men showed greater association in absolute terms.

In addition, surgery resulted in reduced cardiovascular mortality (HR, 0.53, 95 percent CI, 0.34–0.84) and lower cancer mortality (HR, 0.54, 95 percent CI, 0.36–0.80).

This study, however, was limited by its observation design.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
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