Most Read Articles
Roshini Claire Anthony, 5 days ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 09 Nov 2018
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
3 days ago
Type 1 diabetes impairs cognitive functioning in children, and this effect is exacerbated by extreme glycaemic levels, according to a recent meta-analysis.
Pearl Toh, 08 Nov 2018
The pneumonia-causing bacteria, Streptococcus pneumoniae (pneumococcus), can be spread through nose picking and rubbing after exposure of the hands to the bacteria — in addition to the conventionally known route of inhalation of airborne droplets, a study reveals.

Bariatric surgery may facilitate complete resolution of NAFLD in obese individuals

06 Nov 2018

Complete resolution of nonalcoholic fatty liver disease (NAFLD) is highly likely to occur following sustained weight loss in obese patients who have undergone bariatric surgery, although there are still some who may develop new or worsened features of NAFLD, a study has shown.

Researchers performed a systematic review and meta-analysis of studies evaluating liver biopsy results before vs after bariatric surgery in obese patients. Primary endpoints included biopsy-confirmed resolution of NAFLD and NAFLD activity score (NAS). Secondary outcomes were worsening of NAFLD after surgery and liver volume.

Pooled data from 32 cohort studies involving 3,093 biopsies revealed that bariatric surgery led to a biopsy-confirmed resolution of steatosis in 66 percent of patients (95 percent CI, 56–75), inflammation in 50 percent (35–64), ballooning degeneration in 76 percent (64–86) and fibrosis in 40 percent (29–51).

Furthermore, mean NAS substantially dropped after bariatric surgery (mean difference, 2.39; 1.58–3.20; p<0.001).

Interestingly, bariatric surgery resulted in new or worsening NAFLD features, such as fibrosis, in 12 percent (5–20) of patients.

Overall quality of evidence, evaluated using the GRADE approach, was very low.

Although the present data yielded positive results, researchers emphasized the need to further investigate the therapeutic benefits of bariatric surgery for patients with NAFLD.

In a previous study investigating potential predictors of resolution of NAFLD after bariatric surgery, weight loss was associated with decreased alanine aminotransferase (ALT) levels by 6 months postsurgery. Other factors independently associated with ALT decline were improved fasting glycaemia, insulin resistance and dyslipidaemia indices. ALT was used as a surrogate marker of NAFLD. [Diabetes 2018;doi:10.2337/db18-341-OR]

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 5 days ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 09 Nov 2018
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
3 days ago
Type 1 diabetes impairs cognitive functioning in children, and this effect is exacerbated by extreme glycaemic levels, according to a recent meta-analysis.
Pearl Toh, 08 Nov 2018
The pneumonia-causing bacteria, Streptococcus pneumoniae (pneumococcus), can be spread through nose picking and rubbing after exposure of the hands to the bacteria — in addition to the conventionally known route of inhalation of airborne droplets, a study reveals.