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01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
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Bariatric surgery may facilitate complete resolution of NAFLD in obese individuals

06 Nov 2018

Complete resolution of nonalcoholic fatty liver disease (NAFLD) is highly likely to occur following sustained weight loss in obese patients who have undergone bariatric surgery, although there are still some who may develop new or worsened features of NAFLD, a study has shown.

Researchers performed a systematic review and meta-analysis of studies evaluating liver biopsy results before vs after bariatric surgery in obese patients. Primary endpoints included biopsy-confirmed resolution of NAFLD and NAFLD activity score (NAS). Secondary outcomes were worsening of NAFLD after surgery and liver volume.

Pooled data from 32 cohort studies involving 3,093 biopsies revealed that bariatric surgery led to a biopsy-confirmed resolution of steatosis in 66 percent of patients (95 percent CI, 56–75), inflammation in 50 percent (35–64), ballooning degeneration in 76 percent (64–86) and fibrosis in 40 percent (29–51).

Furthermore, mean NAS substantially dropped after bariatric surgery (mean difference, 2.39; 1.58–3.20; p<0.001).

Interestingly, bariatric surgery resulted in new or worsening NAFLD features, such as fibrosis, in 12 percent (5–20) of patients.

Overall quality of evidence, evaluated using the GRADE approach, was very low.

Although the present data yielded positive results, researchers emphasized the need to further investigate the therapeutic benefits of bariatric surgery for patients with NAFLD.

In a previous study investigating potential predictors of resolution of NAFLD after bariatric surgery, weight loss was associated with decreased alanine aminotransferase (ALT) levels by 6 months postsurgery. Other factors independently associated with ALT decline were improved fasting glycaemia, insulin resistance and dyslipidaemia indices. ALT was used as a surrogate marker of NAFLD. [Diabetes 2018;doi:10.2337/db18-341-OR]

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.