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Bariatric surgery could be indicated for gout in obese individuals

5 days ago

Bariatric surgery successfully lowers weight and serum uric acid (SUA) in obese patients with hyperuricaemia and gout, a study reports.

The study used the medical records of 147 patients with obesity who underwent weight-loss surgery. All of them had their body weight and SUA measured at baseline and after the procedure at week 1 and at months, 1, 3, 6, and 12.

A year after the surgery, the patients lost a mean of 30.7 kg (95 percent confidence interval [CI], 28.7–32.7) in weight (p<0.001).

SUA levels, on the other hand, rapidly fell from 419.0 µmol/l (95 percent CI, 400.1–437.8) at baseline to 308.4 µmol/l (95 percent CI, 289.6–327.2) in the first week following surgery. However, it flared to 444.8 µmol/l (95 percent CI, 423.9–465.6) at 1 month before decreasing again to 383.8 µmol/l (95 percent CI, 361.5–406.1) at 3 months, 348.9 µmol/l (95 percent CI, 326.3–371.5) at 6 months, and 327.9 µmol/l (95 percent CI, 305.3–350.5) at 12 months (p<0.001).

Results were consistent in the subgroup of 55 hyperuricaemia and 25 gout patients, with the improvements occurring more rapidly. Baseline SUA levels were above the therapeutic target (≥360 µmmol/l) in all gout patients, but the concentration dropped below this target at 12 months.

The mean reduction in SUA levels was 84.3 µmmol/l (95 percent CI, 63.1–105.4) overall and 163.6 µmmol/l (95 percent CI, 103.9–223.3) in the gout subgroup.

The present data suggest that gout may be considered as an indicator for weight-loss surgery in individuals with severe obesity.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
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