Most Read Articles
Pearl Toh, 20 Nov 2019
The trade-off between the risk of ischaemic vs bleeding events may be different between Asian and non-Asian patients, which warrants careful consideration when deciding on the duration of antiplatelet therapy following a percutaneous coronary intervention (PCI), according to a presentation at ESC Asia Congress 2019.
4 days ago
Participating in a long-distance skiing event may help lower the risk of hypertension, with the number of completed races showing a weak association with the risk, a study has found.
06 Sep 2019
Hypertensive adults with lower plasma zinc concentration are at increased risk of haemorrhagic stroke, especially those with higher body mass index or lower plasma copper levels, a study has found.
06 Jan 2020
Target organ damage appears to be more noticeable in patients affected by primary aldosteronism than those affected by arterial hypertension without primary aldosteronism, suggests a study, adding that specific treatment can ease such condition.

Balloon-expandable, self-expanding valves comparable for TAVI

14 Oct 2019
In intermediate risk patients, the TAVR is found to have better outcomes

Transcatheter aortic valve implantation (TAVI) with either balloon-expandable valves (BEVs) or self-expanding valves (SEVs) yields comparable outcomes, according to a new meta-analysis.

Accessing the databases of PubMed, the Cochrane Library and Embase through 31 March 2019, researchers retrieved eight randomized controlled trials for inclusion in the Bayesian network meta-analysis. The primary outcome of interest was all-cause mortality at the latest follow-up, while secondary outcomes included long-term cardiovascular mortality, stroke, pacemaker implantation, among other vascular events.

The pooled sample included 8,095 patients, of whom 1,976, 2,256 and 3,863 received BEV, SEV and surgical aortic valve replacement, respectively.

Researchers detected no significant difference between BEV and SEV in terms of 30-day all-cause mortality (odds ratio [OR], 0.85, 95 percent CI, 0.34–1.99), cardiovascular mortality (OR, 1.3, 0.58–2.50), stroke (OR, 1.59, 0.37–6.71), bleeding (OR, 0.85, 0.34–1.99) and major vascular complications (OR, 1.30, 0.58–2.50).

Both interventions were likewise comparable for short-term, 30-day moderate to severe paravalvular leak (OR, 0.28, 0.06–1.22).

Long-term outcomes were also similar between BEV and SEV: all-cause mortality (hazard ratio [HR], 1.1, 0.87–1.5), cardiovascular mortality (HR, 1.1, 0.73–1.6), stroke (HR, 1.3, 0.73–2.1), hospitalization (HR, 0.87, 0.41–1.6) and reintervention (HR, 0.68, 0.2–2.3).

Only the difference in the need for new pacemaker reimplantation, both in the short-term (OR, 0.29, 0.11–0.77) and long-term (HR, 0.45, 0.24–0.80) achieved statistical significance, such that BEV patients were less likely to require it.

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Most Read Articles
Pearl Toh, 20 Nov 2019
The trade-off between the risk of ischaemic vs bleeding events may be different between Asian and non-Asian patients, which warrants careful consideration when deciding on the duration of antiplatelet therapy following a percutaneous coronary intervention (PCI), according to a presentation at ESC Asia Congress 2019.
4 days ago
Participating in a long-distance skiing event may help lower the risk of hypertension, with the number of completed races showing a weak association with the risk, a study has found.
06 Sep 2019
Hypertensive adults with lower plasma zinc concentration are at increased risk of haemorrhagic stroke, especially those with higher body mass index or lower plasma copper levels, a study has found.
06 Jan 2020
Target organ damage appears to be more noticeable in patients affected by primary aldosteronism than those affected by arterial hypertension without primary aldosteronism, suggests a study, adding that specific treatment can ease such condition.