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Bacterial infection more prevalent in febrile infants aged 61–90 days than in younger ones

05 Dec 2019

Febrile infants aged between 61 and 90 days appear to have a high prevalence of invasive bacterial infection (IBI), lending support to obtaining urine and blood tests in this population, suggests a recent study.

A total of 3,301 infants were included, among whom 605 (18.3 percent) had a serious bacterial infection (SBI; mainly urinary tract infection). Of those with SBI, 81 (2.5 percent) had IBI (bacteraemia, n=60; meningitis, n=12; sepsis, n=9).

SBI prevalence was 18.5 percent (95 percent confidence interval [CI], 16.4–20.7) among infants >60 days old as compared with 16.6 percent CI, 14.7–18.7) in those between 29 and 60 days and 21.5 percent (95 percent CI, 18.6–24.7) in those <28 days of age.

IBI prevalence was 1.1 percent (95 percent CI, 0.6–2.2) among infants >60 days old as compared with 2.3 percent (95 percent CI, 1.6–3.3; p<0.05) in those 29–60 days and 5.1 percent (95 percent CI, 3.7–7.0; p<0.05) in those <28 days of age. IBI prevalence in well-appearing infants aged >60 days was 1.0 percent (vs 4.5 percent in those <28 days old; p<0.01; and 2.0 percent in those 29–60 days old; p=0.06). Except for one, all infants aged <28 days were diagnosed with bacterial meningitis.

This prospective registry-based cohort study included all infants ≤90 days with fever without a source evaluated in a paediatric emergency department between 2003 and 2017. The prevalence of SBI and IBI was compared in febrile infants <60 days of age and those between 61 and 90 days. 
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Most Read Articles
Pearl Toh, 2 days ago
Every-two-month injections of the long-acting cabotegravir + rilpivirine were noninferior to once-monthly injections for virologic suppression at 48 weeks in people living with HIV*, according to the ATLAS-2M** study presented at CROI 2020 — thus providing a potential option with more convenient dosing.
Stephen Padilla, 19 Mar 2020
The assumption that children are less vulnerable to the coronavirus disease 2019 (COVID-19) compared to adults is not quite true and may even be dangerous, suggests a recent study.
22 Mar 2020
Sustained use of lopinavir-combined regimen appears to confer benefits among patients with the novel coronavirus disease (COVID-19), with improvement possibly indicated by increasing eosinophils, suggests a recent study.
5 days ago
COVID-19 is a novel disease, with no existing immunity. The virus can be transmitted from person to person, quickly and exponentially. Here’s what we can do to slow down the spread, if not contain the outbreak.