Most Read Articles
Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Tristan Manalac, 11 Jan 2019
Less than 15 percent of Singaporean adolescents get the recommended 8–10 hours of sleep on a school night, reports a recent study, noting that such short sleep duration is linked to symptoms of depression, overweight or obesity, and poorer self-rated health.
04 Jan 2019
Obstructive sleep apnoea may increase the risk of male-pattern baldness in men with a family history of hair loss, and this association appears to be mediated by low serum transferrin saturation levels related to hypoxia, a study suggests.
6 days ago
Airway type 2 inflammation remains persistent in many asthmatics on inhaled corticosteroids, a new study has shown. These patients tend to be older and have a more severe disease.

Autotaxin predicts primary biliary cholangitis progression

01 Jun 2018

Serum concentrations of autotaxin (ATX) appear to be associated with disease progression in patients with primary biliary cholangitis (PBC), a recent study has found.

The median ATX level in PBC patients was significantly higher than that in controls (0.97 vs 0.76 mg/L; p<0.0001). This remained true even after stratification according to sex (females: 1.00 vs 0.82 mg/L; p<0.001; males: 0.78 vs 0.76 mg/L; p=0.011).

ATX was also significantly and positively correlated with disease severity. The median ATX values were 0.80, 0.87, 1.03 and 1.70 mg/L for Nakanuma’s classification stages 1, 2, 3 and 4, respectively (r=0.53; p<0.0001). The trend remained even when analysis was confined to females (r=0.54; p<0.0001) or males (r=0.71; p<0.01).

The association persisted even when disease severity was defined according to Scheuer’s classification. Median ATX levels increased from 0.89 mg/L in stage I patients to 1.19 and 1.60 mg/L in stage III and IV patients, respectively (r=0.43; p<0.0001).

Eighteen patients were determined to have Nakanuma’s liver cirrhosis stage 4, while 11 were identified with Scheuer’s stage IV. Receiver operating characteristic (ROC) curve analysis showed that ATX had good diagnostic value for liver cirrhosis in the overall sample (area under ROC [AUROC], 0.925), males (AUROC, 0.984) and females (AUROC, 0.968).

Using a two-site enzyme immunoassay, researchers measured serum ATX levels in 128 treatment-naïve PBC patients (median age 57 years), of whom 108 were female, and 80 healthy controls. Spearman’s rank test was used to determine correlations between serum ATX concentrations and disease stage.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Tristan Manalac, 11 Jan 2019
Less than 15 percent of Singaporean adolescents get the recommended 8–10 hours of sleep on a school night, reports a recent study, noting that such short sleep duration is linked to symptoms of depression, overweight or obesity, and poorer self-rated health.
04 Jan 2019
Obstructive sleep apnoea may increase the risk of male-pattern baldness in men with a family history of hair loss, and this association appears to be mediated by low serum transferrin saturation levels related to hypoxia, a study suggests.
6 days ago
Airway type 2 inflammation remains persistent in many asthmatics on inhaled corticosteroids, a new study has shown. These patients tend to be older and have a more severe disease.