Most Read Articles
6 days ago
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 11 Jun 2018

Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.

3 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
Pearl Toh, 3 days ago
Drinking more water did not significantly slow down the decline in kidney function of patients with stage 3 chronic kidney disease (CKD) at 1 year compared with patients who maintained their daily water intake, the CKD WIT* randomized study suggests.

Autotaxin predicts primary biliary cholangitis progression

01 Jun 2018

Serum concentrations of autotaxin (ATX) appear to be associated with disease progression in patients with primary biliary cholangitis (PBC), a recent study has found.

The median ATX level in PBC patients was significantly higher than that in controls (0.97 vs 0.76 mg/L; p<0.0001). This remained true even after stratification according to sex (females: 1.00 vs 0.82 mg/L; p<0.001; males: 0.78 vs 0.76 mg/L; p=0.011).

ATX was also significantly and positively correlated with disease severity. The median ATX values were 0.80, 0.87, 1.03 and 1.70 mg/L for Nakanuma’s classification stages 1, 2, 3 and 4, respectively (r=0.53; p<0.0001). The trend remained even when analysis was confined to females (r=0.54; p<0.0001) or males (r=0.71; p<0.01).

The association persisted even when disease severity was defined according to Scheuer’s classification. Median ATX levels increased from 0.89 mg/L in stage I patients to 1.19 and 1.60 mg/L in stage III and IV patients, respectively (r=0.43; p<0.0001).

Eighteen patients were determined to have Nakanuma’s liver cirrhosis stage 4, while 11 were identified with Scheuer’s stage IV. Receiver operating characteristic (ROC) curve analysis showed that ATX had good diagnostic value for liver cirrhosis in the overall sample (area under ROC [AUROC], 0.925), males (AUROC, 0.984) and females (AUROC, 0.968).

Using a two-site enzyme immunoassay, researchers measured serum ATX levels in 128 treatment-naïve PBC patients (median age 57 years), of whom 108 were female, and 80 healthy controls. Spearman’s rank test was used to determine correlations between serum ATX concentrations and disease stage.

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Most Read Articles
6 days ago
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 11 Jun 2018

Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.

3 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
Pearl Toh, 3 days ago
Drinking more water did not significantly slow down the decline in kidney function of patients with stage 3 chronic kidney disease (CKD) at 1 year compared with patients who maintained their daily water intake, the CKD WIT* randomized study suggests.