Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Audrey Abella, 6 days ago
A pilot telemedicine initiative may be an alternative for facilitating delivery of intravenous iron (IVI) for individuals requiring iron supplementation.

Atropine keeps myopia at bay in kids

27 Oct 2020
The prevalence rate of myopia amongst preschool children in Hong Kong has tripled from 2.3% to 6.3% in ten years between 1996 and 2006.

High-dose atropine helps slow the progression of high myopia in kids with or at risk of developing the condition, a recent study has found.

Researchers conducted a prospective clinical effectiveness study on 124 children (median age, 9.5 years; 54 percent female) with myopia (≤–2.5 D) or progressive myopia (≥1 D per year). Atropine was given at a 0.5% concentration, and target outcomes included spherical equivalent (SER) and axial length (AL).

The median SER 1 year before the study was –3.88 D, which worsened to –5.03 D by baseline. This indicated a progression of more than 1 D before treatment. More than a third (37.1 percent) of participants had high myopia (SER ≤–6 D), and the median AL was 25.14 mm.

Eighty-nine children (71.8 percent) stated on-treatment over the 3 years of follow-up. Of these, 34.8 percent (n=31) remained on the 0.5% dose, while 36.0 percent (n=32) and 29.2 percent (n=26) saw an increase and decrease in dose, respectively. No AL rebound was reported after dose reduction.

The median annual progression of SER in patients who completed treatment was –0.25 D, while AL increased at a median rate of 0.11 mm per year. On a per-year basis, researchers saw that the progression of SER dropped to 0.00 D in year 1, –0.41 D in year 2, and –0.38 D in year 3. Relative to before treatment, these corresponded to reduction rates of 100 percent, 65 percent, and 68.2 percent (p<0.01 for all).

For those who dropped out, the most common reasons for termination were allergic reactions, photophobia, and non-eye-related adverse events.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Audrey Abella, 6 days ago
A pilot telemedicine initiative may be an alternative for facilitating delivery of intravenous iron (IVI) for individuals requiring iron supplementation.