Most Read Articles
Rachel Soon, 12 Dec 2018

MIMS Pharmacist speaks to Cpt. Manvikram Singh Gill, military pharmacist with the Royal Medical and Dental Corps (RMDC) of the Malaysian Armed Forces (MAF),about his work at the Rohingya refugee camp in Cox's Bazar, Bangladesh.

Ms Penny Wong Pei Nee, 12 Jul 2018
Antibiotics, also known as antibacterials, are a group of medications that either destroy the infecting bacteria or slow down their growth.
Elaine Soliven, 30 Jun 2020
Treatment with Lactobacillus crispatus CTV-05 (Lactin-V) significantly reduces the incidence of bacterial vaginosis recurrence in women who were previously treated with vaginal metronidazole, according to a recent study.
Jairia Dela Cruz, 20 May 2020
Concomitant use of fimasartan and rosuvastatin in patients with hypertension and dyslipidaemia does not appear to be synergistic in increasing concurrent control rate of the diseases, although either drug is effective against the target disease, according to a study.

Atropine 0.05% trumps 0.01% concentration in slowing myopia progression

28 Jun 2020

Atropine 0.05% has double the efficacy of 0.01% eye drops over 2 years, and the former remains the optimal concentration among atropine concentrations in slowing the progression of myopia, a recent study has shown.

Of the 438 children originally randomized to receive 0.05%, 0.025%, 0.01%, or placebo once daily in both eyes in the Low-Concentration Atropine for Myopia Progression (LAMP) phase I study, 383 (87 percent; aged 4-12 years) with myopia of at least –1.0 dioptre (D) were selected to continue in the extended trial (phase II).

Children in the placebo group (LAMP phase I) were switched to receive 0.05% atropine from the beginning of the second-year follow-up. Those in the 0.05%, 0.025%, and 0.01% atropine groups remained in the same regimen. The investigators measured cycloplegic refraction, axial length (AL), accommodation amplitude, photopic and mesopic pupil diameter, and best-corrected visual acuity at 4-month intervals.

The mean spherical equivalent (SE) over the 2-year period was 0.55±0.86 D in the 0.05% (p=0.015), 0.85±0.73 D in the 0.025% (p<0.001), and 1.12±0.85 D in the 0.01% atropine groups (p=0.02), with mean AL changes of 0.39±0.35 mm (p=0.04), 0.50±0.33 mm (p<0.001), and 0.59±0.38 mm (p=0.10), respectively, over 2 years.

Compared with year 1, the efficacy of 0.05% and 0.025% atropine at year 2 remained similar (p>0.1), while that in the 0.01% concentration improved slightly (p=0.04).

Switching to 0.05% atropine significantly reduced myopia progression for the phase I placebo group (SE change, 0.18 D in year 2 vs 0.82 D in year 1; p<0.001; AL elongated 0.15 mm in year 2 vs 0.43 mm in year 1; p<0.001).

“Accommodation loss and change in pupil size in all concentrations remained similar to the first-year results and were well tolerated,” the investigators noted. “Visual acuity and vision-related quality of life remained unaffected.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Pharmacist - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Rachel Soon, 12 Dec 2018

MIMS Pharmacist speaks to Cpt. Manvikram Singh Gill, military pharmacist with the Royal Medical and Dental Corps (RMDC) of the Malaysian Armed Forces (MAF),about his work at the Rohingya refugee camp in Cox's Bazar, Bangladesh.

Ms Penny Wong Pei Nee, 12 Jul 2018
Antibiotics, also known as antibacterials, are a group of medications that either destroy the infecting bacteria or slow down their growth.
Elaine Soliven, 30 Jun 2020
Treatment with Lactobacillus crispatus CTV-05 (Lactin-V) significantly reduces the incidence of bacterial vaginosis recurrence in women who were previously treated with vaginal metronidazole, according to a recent study.
Jairia Dela Cruz, 20 May 2020
Concomitant use of fimasartan and rosuvastatin in patients with hypertension and dyslipidaemia does not appear to be synergistic in increasing concurrent control rate of the diseases, although either drug is effective against the target disease, according to a study.