Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Atrial fibrillation worsens limb revascularization in PAD patients

10 Nov 2019

Atrial fibrillation (AF) is tied to poorer outcomes in patients with peripheral artery disease (PAD) who undergo limb revascularization, a recent study has found.

Of 2,283,568 patients who underwent limb revascularization procedures from 2002 to 2014, 12.9 percent (n=294,469; mean age, 76.1±10.0 years; 45.6 percent female) had AF. Critical limb ischaemia (CLI) was more common among AF patients, while intermittent claudication (IC) was more prevalent in the non-AF group.

Multivariable logistic regression analysis found that AF increased the risk of in-hospital mortality among PAD patients undergoing surgical revascularization (6.4 percent vs 2.5 percent; adjusted odds ratio [OR], 1.09, 95 percent confidence intervals [CI], 1.05–1.12). The overall length of hospital stay was significantly longer than in non-AF counterparts (p<0.001).

Moreover, myocardial infarction (5.7 percent vs 3.0 percent; adjusted OR, 1.12, 95 percent CI, 1.09–1.16; p<0.001), postprocedural stroke (9.0 percent vs 6.2 percent; adjusted OR, 1.42, 95 percent CI, 1.37–1.48; p<0.001) and major bleeding (10.6 percent vs 6.2 percent; adjusted OR, 1.20, 95 percent CI, 1.18–1.23; p<0.001) all remained significantly more likely to occur in AF patients.

The same was true for major (19.1 percent vs 10.9 percent; adjusted OR, 1.22, 95 percent CI, 1.20–1.25; p<0.001) and net (28.9 percent vs 18.3 percent; adjusted OR, 1.22, 95 percent CI, 1.20–1.24; p<0.001) adverse cardiovascular events.

The effects of AF on worse outcomes remained consistent in patients who underwent endovascular interventions. Subgroup analysis according to those with IC or CLI likewise did not meaningfully change the principal findings.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.