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Atrial fibrillation strongly predicts stroke in males

16 Nov 2018

Atrial fibrillation appears to be the strongest determinant of stroke over 48 years of follow-up in males, a study has found.

The study followed 854 men from the age of 50 to 98 years. All participants underwent repeated medical examinations and completed lifestyle questionnaires.

Cox proportional hazards analysis revealed several determinants of ischaemic stroke, as follows: atrial fibrillation (hazard ratio [HR], 6.61; 95 percent CI, 4.47–9.77), mother dead from cardiovascular disease (HR, 1.53; 1.09–2.17), high education (HR, 0.81; 0.69–0.96) and increased physical activity level during leisure time (HR, 0.68; 0.50–0.93).

Meanwhile, haemorrhagic stroke risk was associated with heart rate (HR, 1.04; 1.01–1.06) and mother dead from stroke (HR, 3.56; 1.43–8.87).

Significant factors associated with all stroke included atrial fibrillation (HR, 5.34; 3.68–7.75), high diastolic blood pressure (HR, 1.02; 1.01–1.03), increased body weight (HR, 0.96; 0.94–0.99), high educational level (HR, 0.79; 0.68–0.92), wide waist circumference (HR, 1.04; 1.01–1.07), smoking (HR, 1.25; 1.06–1.48), mother dead from cerebrovascular disease (HR, 1.43; 1.05–1.94) and diabetes mellitus (HR, 1.65; 1.02–2.68).

Notably, stroke occurred in 88 percent of men diagnosed with atrial fibrillation.

The findings underscore a need for improved prophylaxis through intense treatment of modifiable determinants, researchers said.

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Most Read Articles
04 Feb 2019
The carbon-chain length of saturated fatty acids appears to be an important factor in determining its role in cardiovascular health, a recent study has found.
6 days ago
Olanzapine confers a modest therapeutic effect on weight compared with placebo in adult outpatients with anorexia nervosa, a study has shown. However, it does not appear to offer significant benefit for psychological symptoms.
Pearl Toh, 3 days ago
A latest study at ISC 2019 shows that even patients with large-core stroke damage can have a good outcome after mechanical clot removal with endovascular thrombectomy (EVT), depending on the size of the infarct and time lapses between stroke onset and treatment.
Jairia Dela Cruz, 04 Feb 2019
Treatment with secukinumab results in a higher rate of remission or low-disease activity at week 16 in patients with psoriatic arthritis as compared with placebo, according to a posthoc analysis of the FUTURE 2 study. This effect is sustained at 2 years and is evident in both tumour necrosis factor inhibitor-experienced and -naïve patients.