Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Atopic dermatitis presenting at a later age appears easier to control

27 Nov 2019

Earlier-onset atopic dermatitis (AD) in children appears to correlate with stronger persistence over time and worse disease control, a recent study has found.

Researchers conducted a prospective observational study of 8,015 patients (median age at enrolment, 6.6 years; 53.3 percent female) with childhood-onset AD. Specific age of onset was determined according to caregiver interviews. The primary study outcome was AD disease control and persistence, assessed using guardian and patient interviews.

Over 41,934 person-years of follow-up, study participants accomplished a total of 70,841 surveys, corresponding to a mean of 8.8 surveys each. These revealed three distinct timing patterns of AD onset: early (<2 years; n=5,770), mid (3–7 years; n=1,492) and late (8–17 years; n=712) onset. The median age at AD onset was 0.75 years.

Sixteen percent of all surveys indicated complete control of the disease, while 5.2 percent showed uncontrolled AD. Good and limited control, on the other hand, was found on 50.2 percent and 28.6 percent of all surveys.

Patients whose AD presented at an older age enjoyed significantly better disease control and less AD persistence. For instance, each additional year of AD onset correlated with a 7-percent decline in the odds of worse control (adjusted odds ratio [OR], 0.93, 95 percent confidence intervals [CI], 0.91–0.94).

In absolute terms, 10-year-olds experiencing AD onset were 44-percent less likely to experience worse disease control than a counterpart whose disease onset occurred at 2 years.

Analysis according to patient subgroups showed that relative to the early-onset AD patients, the risk of poor control was lower in those with mid-onset (adjusted OR, 0.71, 0.64–0.80) and late-onset (adjusted OR, 0.51, 0.43–0.60) disease.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.