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Atherogenic index of plasma higher in men with erectile dysfunction

09 Aug 2020
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Patients with erectile dysfunction (ED) have elevated values of atherogenic index of plasma (AIP), a recent study has found.

The study included 124 ED patients (mean age, 46.7±9.6 years) and 126 controls (mean age, 47.8±9.1 years). Erectile function was evaluated in accordance with the International Index of Erectile Function (IIEF-5) questionnaire. Blood samples were collected for the measurement of lipid levels, which in turn were used for the calculation of the AIP.  

ED patients had significantly higher mean AIP values than controls (0.45±0.27 vs 0.37±0.27; p=0.015). Upon exercise stress testing (EST), ED patients showed significantly lower max heart rate (162.8±6.1 vs 165±8.7; p=0.019), as well as metabolic equivalent score (METs; 11.1±2.2 vs 11.6±2.2; p=0.045).

Researchers also found that AIP rose with increasing ED severity (mild: 0.37±0.25; mild–moderate: 0.46±0.27; moderate: 0.48±0.25; severe: 0.59±0.41), although statistical significance was not achieved (p=0.18).

On the other hand, both METs (p=0.026) and max heart rate (p=0.018) under EST dropped significantly progressively with increasing ED severity.

Logistic ordinal regression analysis confirmed the significant and inverse correlation between AIP and ED (odds ratio, –1.143, 95 percent confidence interval, –2.646 to –0.181; p=0.025). AIP was also negatively associated with high-density lipoprotein cholesterol, and negatively with glucose and glycated haemoglobin concentrations (p<0.001 for all).

“[I]t should be kept in mind that each patient with ED is also a vascular patient or candidate,” researchers said. “This is especially true for patients whose ED is not thought to be hormonal, neurological, or psychological in origin.”

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Most Read Articles
5 days ago
Chest pain appears to be the principal complaint of patients hospitalized with a first myocardial infarction (MI), particularly among those in the youngest age group, a study has found.
Jairia Dela Cruz, 16 Sep 2020
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 5 days ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
6 days ago
Women with pre-eclampsia are at higher risk of developing heart failure, a study suggests.