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Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Roshini Claire Anthony, 13 Nov 2020

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Pearl Toh, 6 days ago
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Elvira Manzano, 17 Nov 2020
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Asymptomatic cases pose challenge in identifying children with COVID-19

04 Apr 2020

An observational cohort study in Zhejiang, China, has seen many asymptomatic children with the novel coronavirus disease (COVID-19), demonstrating the difficulty in isolating paediatric patients who do not have clear epidemiological information. In addition, this poses a serious situation in community-acquired infections.

The investigators retrospectively retrieved data for children (aged 0–16 years) with confirmed COVID-19 from electronic medical records in three hospitals in Zhejiang. The epidemiological and clinical features of these paediatric patients were recorded.

Thirty-six children (mean age, 8.3 years) were identified to be infected with severe acute respiratory syndrome coronavirus 2, the causative agent of COVID-19, from 17 January to 1 March 2020.

The most common route of transmission was by close contact with infected family members (n=32; 89 percent), followed by a history of exposure to the epidemic area (n=12; 33 percent). Eight patients (22 percent) had both exposures.

Of the infected children, 19 (53 percent) had moderate COVID-19 with pneumonia and 17 (47 percent) had mild clinical type. Among those with mild COVID-19, 10 were asymptomatic and seven had acute upper respiratory symptoms.

Fever (n=13; 36 percent) and dry cough (n=7; 19 percent) were common symptoms on admission. Four febrile patients had a body temperature of 38.5 °C, and nine with 37.5–38.5 °C.

Abnormal laboratory findings typically included elevated creatinine kinase MB (n=11; 31 percent), decreased lymphocytes (n=11; 31 percent), leucopaenia (n=7; 19 percent) and elevated procalcitonin (n=6; 17 percent).

Other variables associated with COVID-19 severity apart from radiographic presentations were as follows: decreased lymphocytes, elevated body temperature, and high levels of procalcitonin, D-dimer and creatinine kinase MB.

All paediatric patients were treated with interferon alfa by aerosolization twice a day. Fourteen children (39 percent) received lopinavir-ritonavir syrup twice a day, and six (17 percent) required oxygen inhalation. Mean hospitalization was 14 days. All patients recovered by 28 February 2020.

The COVID-19 outbreak started in Wuhan, China, and led to a global pandemic due to alleged censorship and delayed travel restrictions by the Chinese government. It has infected more than 800,000 people, with nearly 40,000 deaths, across the world as of this writing.

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Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Pearl Toh, 6 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Elvira Manzano, 17 Nov 2020
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.