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01 Dec 2020
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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.

Assisted reproductive technology poses no ovarian cancer risk

21 Dec 2020

Assisted reproductive technology (ART) does not promote the development of ovarian tumours, and the risk increase seen in ART-treated women is likely related to nulliparity instead, according to a study.

The study included 30,625 women who received ovarian stimulation for ART and 9,988 subfertile women not treated with ART. The mean number of ART cycles was 3.3, and more women in the ART group remained nulliparous (35.4 percent vs 25.2 percent). Follow-up duration was longer in the non-ART control group (25.7 vs 23.4 years), and so at end of follow-up, the group was older than the group of women who received ART (median age, 57.0 vs 55.9 years).

Over a median follow-up of 24 years, a total of 158 invasive and 100 borderline ovarian tumours occurred. Ovarian cancer risk was higher in the ART group than in the general population (standardized incidence ratio [SIR], 1.43, 95 percent confidence interval [CI], 1.18–1.71) but not significantly different relative to the non-ART group (adjusted hazard ratio [HR], 1.02, 95 percent CI, 0.70–1.50).

The risk was lower among women with higher parity and with a larger number of successful ART cycles (resulting in childbirth, ptrend=0.001). On the other hand, there was no association observed for the number of unsuccessful ART cycles.

Meanwhile, borderline ovarian tumour risk was elevated in the ART group compared with both the general population (SIR, 2.20, 95 percent CI, 1.66–2.86) and the non-ART group (HR, 1.84, 95 percent CI, 1.08–3.14). A higher number of ART cycles or longer follow-up time did not modify the risk.

More studies are needed to examine the role of ART in the aetiology of borderline ovarian tumours.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.