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Aspirin use improves overall survival in patients with melanoma

09 May 2018

Postdiagnosis use of aspirin has been shown to provide a survival advantage in patients with melanoma, a recent study has shown.

An association existed between aspirin use and longer overall survival in univariate analysis and after controlling for age, sex, stage and treatment modalities (hazard ratio [HR], 0.58; 95 percent CI, 0.45–0.75). Aspirin use did not correlate with survival in patients with in situ and stage I melanoma, but it correlated with better survival in stages II (HR, 0.45; 0.24–0.82) and III (HR, 0.57; 0.34–0.96).

There was no statistical significance seen in stage IV patients (HR, 0.55; 0.27–1.13). Furthermore, melanoma was less likely to be diagnosed in stages III or IV among those using aspirin prior to diagnosis.

To determine whether aspirin confers longer survival in patients with melanoma, the authors conducted a retrospective cohort study of 1,522 patients at Indiana University Health who had melanoma diagnosed between 2000 and 2014, and were followed up through September 2016.

“Clinical trials investigating the therapeutic potential of aspirin are warranted,” the authors said, adding that the study was limited by its observational design.

In a previous meta-analysis, results support the therapeutic efficacy of adjuvant interferon alpha for the treatment of patients with high-risk cutaneous melanoma in terms of both disease-free survival and overall survival, to a lower extent. Additionally, interferon is valid as a reference treatment in trials investigating new therapeutic agents for the adjuvant treatment of this population. [Cochrane Database Syst Rev 2013;doi:10.1002/14651858.CD008955.pub2]

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Most Read Articles
6 days ago
Cardiac biomarkers are useful for identifying community-acquired pneumonia (CAP) patients with an elevated risk of early and long-term cardiovascular (CV) events, according to a study.
3 days ago
Tofogliflozin is safe and effective for elderly patients with type 2 diabetes mellitus (T2DM), regardless of insulin and oral antidiabetic drugs, reports a new Japan study.
17 Aug 2019
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
19 Aug 2019
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.