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Aspirin use improves overall survival in patients with melanoma

09 May 2018

Postdiagnosis use of aspirin has been shown to provide a survival advantage in patients with melanoma, a recent study has shown.

An association existed between aspirin use and longer overall survival in univariate analysis and after controlling for age, sex, stage and treatment modalities (hazard ratio [HR], 0.58; 95 percent CI, 0.45–0.75). Aspirin use did not correlate with survival in patients with in situ and stage I melanoma, but it correlated with better survival in stages II (HR, 0.45; 0.24–0.82) and III (HR, 0.57; 0.34–0.96).

There was no statistical significance seen in stage IV patients (HR, 0.55; 0.27–1.13). Furthermore, melanoma was less likely to be diagnosed in stages III or IV among those using aspirin prior to diagnosis.

To determine whether aspirin confers longer survival in patients with melanoma, the authors conducted a retrospective cohort study of 1,522 patients at Indiana University Health who had melanoma diagnosed between 2000 and 2014, and were followed up through September 2016.

“Clinical trials investigating the therapeutic potential of aspirin are warranted,” the authors said, adding that the study was limited by its observational design.

In a previous meta-analysis, results support the therapeutic efficacy of adjuvant interferon alpha for the treatment of patients with high-risk cutaneous melanoma in terms of both disease-free survival and overall survival, to a lower extent. Additionally, interferon is valid as a reference treatment in trials investigating new therapeutic agents for the adjuvant treatment of this population. [Cochrane Database Syst Rev 2013;doi:10.1002/14651858.CD008955.pub2]

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
09 Jan 2020
Acute ischaemic stroke patients who are current or recent smokers are at greater odds of having unfavourable functional outcomes 3 months after the index event, a study has found.
Stephen Padilla, 2 days ago
Brodalumab has exhibited long-term efficacy and consistent safety profile for more than 2 years in the treatment of patients with psoriasis, results of the phase III AMAGINE-2 trial show.
3 days ago
Anaemia increases mortality risk in heart failure (HF) patients across the ejection fraction (EF) spectrum, a recent study has found. The effect appears to be stronger in preserved (HFpEF) and midrange (HFmrEF) than in reduced (HFrEF) EF disease.