Most Read Articles
Elvira Manzano, 02 Oct 2018
Triple therapy with budesonide, glycopyrrolate, and formoterol in one metered dose inhaler (BGF MDI) appears effective and is well-tolerated in patients with symptomatic moderate-to-severe chronic obstructive pulmonary disease (COPD) irrespective of exacerbation history, the multicentre, phase III KRONOS* trial has shown.
Dr. Fanny Wai-San Ko, Dr. Wing-Ho Yip, 15 Aug 2018
Although a majority of patients can achieve good asthma control with the use of inhaled corticosteroid (ICS) and bronchodilators, some patients’ asthma remain uncontrolled despite the use of these medications.
Stephen Padilla, 14 Jan 2019
Overall, the risk of lung cancer is higher in former and current smokers with higher concentrations of high sensitivity C-reactive protein (hsCRP), according to a study. Additionally, circulating hsCRP is not associated with the risk of lung adenocarcinoma and may reflect a prediagnostic disease state rather than a causal risk for lung cancer.
20 Feb 2018
Dr Michael Lim, consultant of the Division of Paediatric Pulmonary and Sleep in National University Hospital, Singapore, shares his insights with Pearl Toh on diagnosing and managing paediatric asthma in the primary care setting.

Aspirin use beneficial to patients with AECOPD

08 Mar 2018

Aspirin use in patients with acute exacerbation of chronic obstructive pulmonary disorder (AECOPD) is associated with lower rates of in-hospital mortality, reduced use of invasive mechanical ventilation and shorter hospital length-of-stay, a study suggests.

Researchers looked at 206,686 patients aged ≥40 years with hospitalization for AECOPD, which included 13,826 (7 percent) aspirin users. Compared with nonusers, aspirin users were older and more likely to have comorbidities (p<0.001).

In regression models, aspirin use was significantly associated with lower in-hospital mortality (adjusted odds ratio [OR], 0.60; 95 percent CI, 0.50–0.72; p<0.001) and lower rate of invasive mechanical ventilation use (adjusted OR, 0.64; 0.55–0.73; p<0.001).

No significant difference in the rate of noninvasive positive pressure ventilation use was observed between aspirin users and nonusers (adjusted OR, 1.05; 0.98–1.12; p=0.20).

Hospital length-of-stay was significantly shorter in aspirin users vs nonusers (median, 3 vs 4 days). Specifically, aspirin use was associated with a 7-percent decrease in length-of-stay (p<0.001).

The point estimates of the said associations did not change significantly in a sensitivity analysis excluding patients with history of coronary artery diseases, ischaemic stroke and/or heart failure.

Although causal inferences remain premature, the present data, along those from prior studies demonstrating the benefits of aspirin use in COPD patients, suggest that aspirin—a widely used and inexpensive medication—represents a potential therapeutic option in the management of COPD, researchers said.

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Most Read Articles
Elvira Manzano, 02 Oct 2018
Triple therapy with budesonide, glycopyrrolate, and formoterol in one metered dose inhaler (BGF MDI) appears effective and is well-tolerated in patients with symptomatic moderate-to-severe chronic obstructive pulmonary disease (COPD) irrespective of exacerbation history, the multicentre, phase III KRONOS* trial has shown.
Dr. Fanny Wai-San Ko, Dr. Wing-Ho Yip, 15 Aug 2018
Although a majority of patients can achieve good asthma control with the use of inhaled corticosteroid (ICS) and bronchodilators, some patients’ asthma remain uncontrolled despite the use of these medications.
Stephen Padilla, 14 Jan 2019
Overall, the risk of lung cancer is higher in former and current smokers with higher concentrations of high sensitivity C-reactive protein (hsCRP), according to a study. Additionally, circulating hsCRP is not associated with the risk of lung adenocarcinoma and may reflect a prediagnostic disease state rather than a causal risk for lung cancer.
20 Feb 2018
Dr Michael Lim, consultant of the Division of Paediatric Pulmonary and Sleep in National University Hospital, Singapore, shares his insights with Pearl Toh on diagnosing and managing paediatric asthma in the primary care setting.