Most Read Articles
25 Jun 2018
A recent study has enumerated the following features that characterize patients treated in the emergency department (ED) for acute exacerbation of chronic obstructive pulmonary disease (AECOPD): they commonly arrive by ambulance, have a high admission rate and have significant in-hospital mortality.
09 Jun 2018
A nationwide study has shown complex use patterns of long-acting beta2‐agonists (LABAs), long‐acting muscarinic antagonists (LAMAs) and inhaled corticosteroids (ICSs) in patients with chronic obstructive pulmonary disease (COPD). Often, such patterns do not comply with treatment guidelines.
10 Mar 2019
A recent study has found that patients with obstructive sleep apnoea (OSA) prefer nasal masks during continuous positive airway pressure (CPAP) initiation.
Pearl Toh, 16 Feb 2019
Vitamin D supplements can help reduce the rate of moderate-to-severe COPD* exacerbations in patients with inadequate vitamin D levels (<25 nmol/L) at baseline, but not in those with higher levels, according to a meta-analysis of randomized controlled trials (RCTs).

Aspirin use beneficial to patients with AECOPD

08 Mar 2018

Aspirin use in patients with acute exacerbation of chronic obstructive pulmonary disorder (AECOPD) is associated with lower rates of in-hospital mortality, reduced use of invasive mechanical ventilation and shorter hospital length-of-stay, a study suggests.

Researchers looked at 206,686 patients aged ≥40 years with hospitalization for AECOPD, which included 13,826 (7 percent) aspirin users. Compared with nonusers, aspirin users were older and more likely to have comorbidities (p<0.001).

In regression models, aspirin use was significantly associated with lower in-hospital mortality (adjusted odds ratio [OR], 0.60; 95 percent CI, 0.50–0.72; p<0.001) and lower rate of invasive mechanical ventilation use (adjusted OR, 0.64; 0.55–0.73; p<0.001).

No significant difference in the rate of noninvasive positive pressure ventilation use was observed between aspirin users and nonusers (adjusted OR, 1.05; 0.98–1.12; p=0.20).

Hospital length-of-stay was significantly shorter in aspirin users vs nonusers (median, 3 vs 4 days). Specifically, aspirin use was associated with a 7-percent decrease in length-of-stay (p<0.001).

The point estimates of the said associations did not change significantly in a sensitivity analysis excluding patients with history of coronary artery diseases, ischaemic stroke and/or heart failure.

Although causal inferences remain premature, the present data, along those from prior studies demonstrating the benefits of aspirin use in COPD patients, suggest that aspirin—a widely used and inexpensive medication—represents a potential therapeutic option in the management of COPD, researchers said.

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Most Read Articles
25 Jun 2018
A recent study has enumerated the following features that characterize patients treated in the emergency department (ED) for acute exacerbation of chronic obstructive pulmonary disease (AECOPD): they commonly arrive by ambulance, have a high admission rate and have significant in-hospital mortality.
09 Jun 2018
A nationwide study has shown complex use patterns of long-acting beta2‐agonists (LABAs), long‐acting muscarinic antagonists (LAMAs) and inhaled corticosteroids (ICSs) in patients with chronic obstructive pulmonary disease (COPD). Often, such patterns do not comply with treatment guidelines.
10 Mar 2019
A recent study has found that patients with obstructive sleep apnoea (OSA) prefer nasal masks during continuous positive airway pressure (CPAP) initiation.
Pearl Toh, 16 Feb 2019
Vitamin D supplements can help reduce the rate of moderate-to-severe COPD* exacerbations in patients with inadequate vitamin D levels (<25 nmol/L) at baseline, but not in those with higher levels, according to a meta-analysis of randomized controlled trials (RCTs).