Most Read Articles
26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
Elaine Soliven, 20 May 2020
Early treatment with a triple antiviral combination of lopinavir-ritonavir, ribavirin, and interferon beta-1b significantly shortens the duration of virus shedding and reduces symptoms in patients with mild-to-moderate COVID-19 compared with lopinavir-ritonavir only, according to a recent study.
Pearl Toh, 26 Sep 2019
The Singapore Health Sciences Authority (HSA) has recalled eight brands of ranitidine products containing trace amounts of the nitrosamine impurity NDMA*, which is a potential human carcinogen.
Rachel Soon, 24 Apr 2019

With recent recalls of losartan-containing products contaminated by potentially carcinogenic nitrosamines, MIMS speaks to the Malaysian National Pharmaceutical Regulatory Agency (NPRA) for more details.

Aspirin potentially protective against fracture

27 Mar 2020

Aspirin use in adults results in lower fracture risk and higher bone mass density (BMD) at the spine and the hip, according to the results of a meta-analysis.

Researchers searched multiple online databases for studies evaluating the effect of aspirin in terms of fracture risk or changes in BMD (measured by dual energy X-ray absorptiometry [DXA]) in men and women. Data on aspirin dose and duration were obtained either via self-report or identified through prescription histories. Fracture outcomes included the number or rate of any fractures confirmed by imaging, while BMD outcomes comprised measures of bone mass of the whole body as well as at the total hip, proximal femur, femoral neck, and spine or lumbar regions.

The meta-analysis included 12 studies, with data pooled using random-effects models. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklists for observational studies.

Aspirin use reduced the odds of any fracture by 17 percent (odds ratio, 0.83, 95 percent confidence interval [CI], 0.70–0.99; I2, 71 percent; six studies; n=511,390).

Compared with nonusers, aspirin users also exhibited a higher total hip BMD, which was true for both women (standardized mean difference [SMD], 0.03, 95 percent CI, −0.02 to 0.07; I2, 0 percent; three studies; n=9,686) and men (SMD, 0.06, 95 percent CI, −0.02 to 0.13; I2, 0 percent; two studies; n=4,137), although these associations were not significant. Results were similar for lumbar spine BMD in women (SMD, 0.03, 95 percent CI, −0.03 to 0.09; I2, 34 percent; four studies; n=11,330) and men (SMD, 0.08; 95 percent CI, −0.01 to 0.18; one study; n=432).

The researchers pointed out that although the reduction in fracture risk was small, such reductions might yield considerable benefits at a population level, given the widespread use of aspirin and the high prevalence of undetected low bone density.

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Most Read Articles
26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
Elaine Soliven, 20 May 2020
Early treatment with a triple antiviral combination of lopinavir-ritonavir, ribavirin, and interferon beta-1b significantly shortens the duration of virus shedding and reduces symptoms in patients with mild-to-moderate COVID-19 compared with lopinavir-ritonavir only, according to a recent study.
Pearl Toh, 26 Sep 2019
The Singapore Health Sciences Authority (HSA) has recalled eight brands of ranitidine products containing trace amounts of the nitrosamine impurity NDMA*, which is a potential human carcinogen.
Rachel Soon, 24 Apr 2019

With recent recalls of losartan-containing products contaminated by potentially carcinogenic nitrosamines, MIMS speaks to the Malaysian National Pharmaceutical Regulatory Agency (NPRA) for more details.