Most Read Articles
30 Nov 2018
New drug applications approved by US FDA as of 16 - 30 November 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Roshini Claire Anthony, 4 days ago

A combination of tocilizumab and methotrexate reduced disease activity at 2 years compared with methotrexate plus prednisone in patients with early rheumatoid arthritis (RA), an effect not demonstrated with tocilizumab monotherapy.

Roshini Claire Anthony, 2 days ago

The use of intramuscular depot medroxyprogesterone acetate (DMPA-IM) did not increase a woman’s risk of acquiring HIV compared with the use of a copper intrauterine device (IUD) or a levonorgestrel implant, results of a study conducted by the ECHO* Trial Consortium show.

14 May 2019
At the recent GLYCEMIC GUARDIANS™ dinner symposium, three eminent speakers spoke on theindispensable role of medical nutrition therapy (MNT) in improving outcomes for patients with type2 diabetes (T2D).

Aspirin may increase rate of haemorrhagic events in elderly hypertensive patients

07 Jun 2019
For nearly 100 years, aspirin has been a common drug used for pain relief and fever treatment.

Low-dose aspirin therapy does not confer significant benefits to elderly patients with hypertension, but treatment appears to increase the risk of haemorrhagic events, suggest a Japan study.

Aspirin therapy in hypertensive patients did not improve the primary outcome of death from cardiovascular disease, nonfatal stroke and nonfatal myocardial infarction, but it was significantly associated with higher incidence of serious extracranial haemorrhage (hazard ratio [HR], 1.81, 95 percent CI, 1.18–2.77; p=0.0064) and haemorrhagic stroke (HR, 1.75, 0.99–3.07; p=0.053).

Furthermore, aspirin did not significantly influence the primary outcome in any of the blood pressure (BP) subgroups. Aspirin even increased the incidence of haemorrhagic stroke in the high BP group (HR, 3.51, 1.29–9.51; p=0.014). Moreover, there was an increase, or a tendency to increase, in extracranial haemorrhage in the moderate (HR, 2.53, 1.18–5.45; p=0.017) and high (HR, 2.14, 1.00–4.56; p=0.050) BP groups.

The investigators used data from patients aged 60–85 years with hypertension, dyslipidaemia and/or diabetes, but without cardiovascular disease, of the Japanese Primary Prevention Project to examine whether BP influenced the efficacy of low-dose acetylsalicylic acid for the primary prevention of cardiovascular events.

A total of 12,278 patients were assigned to aspirin (100 mg/day) or no aspirin and were further categorized into BP subgroups: low (average systolic BP form the baseline to the year of the events, <130 mm Hg), moderate (130 and <140 mm Hg) and high (≥140 mm Hg). Mean duration of follow-up was 5.02 years.

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Most Read Articles
30 Nov 2018
New drug applications approved by US FDA as of 16 - 30 November 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Roshini Claire Anthony, 4 days ago

A combination of tocilizumab and methotrexate reduced disease activity at 2 years compared with methotrexate plus prednisone in patients with early rheumatoid arthritis (RA), an effect not demonstrated with tocilizumab monotherapy.

Roshini Claire Anthony, 2 days ago

The use of intramuscular depot medroxyprogesterone acetate (DMPA-IM) did not increase a woman’s risk of acquiring HIV compared with the use of a copper intrauterine device (IUD) or a levonorgestrel implant, results of a study conducted by the ECHO* Trial Consortium show.

14 May 2019
At the recent GLYCEMIC GUARDIANS™ dinner symposium, three eminent speakers spoke on theindispensable role of medical nutrition therapy (MNT) in improving outcomes for patients with type2 diabetes (T2D).