Most Read Articles
Rachel Soon, 5 days ago

On 8 August, the first town hall held by the Ministry of Health (MOH) with members of the pharmacy profession took place in Putrajaya. Over 500 pharmacists from across the country and from different areas of practice—community and hospital, public and private, academy and industry—converged to fill the auditorium for the chance to engage in direct dialogue with MOH.

Jackey Suen, 08 Oct 2018

Adding pertuzumab to trastuzumab plus an aromatase inhibitor (AI) improves progression-free survival (PFS) in patients with HER2-positive metastatic or locally advanced breast cancer, the phase II PERTAIN study has shown.

05 Aug 2019
Use of alpha blockers in the treatment of hypertension in women is associated with an increased risk of hypotension and related events as compared with other blood pressure-lowering drugs, as reported in a recent study.
Laura Kho Sui San , 29 May 2019
Anxiety becomes a pathological disorder when it occurs for no detectable reason, persists and interferes with daily activities like work performance and relationships.

Aspirin may increase rate of haemorrhagic events in elderly hypertensive patients

07 Jun 2019
For nearly 100 years, aspirin has been a common drug used for pain relief and fever treatment.

Low-dose aspirin therapy does not confer significant benefits to elderly patients with hypertension, but treatment appears to increase the risk of haemorrhagic events, suggest a Japan study.

Aspirin therapy in hypertensive patients did not improve the primary outcome of death from cardiovascular disease, nonfatal stroke and nonfatal myocardial infarction, but it was significantly associated with higher incidence of serious extracranial haemorrhage (hazard ratio [HR], 1.81, 95 percent CI, 1.18–2.77; p=0.0064) and haemorrhagic stroke (HR, 1.75, 0.99–3.07; p=0.053).

Furthermore, aspirin did not significantly influence the primary outcome in any of the blood pressure (BP) subgroups. Aspirin even increased the incidence of haemorrhagic stroke in the high BP group (HR, 3.51, 1.29–9.51; p=0.014). Moreover, there was an increase, or a tendency to increase, in extracranial haemorrhage in the moderate (HR, 2.53, 1.18–5.45; p=0.017) and high (HR, 2.14, 1.00–4.56; p=0.050) BP groups.

The investigators used data from patients aged 60–85 years with hypertension, dyslipidaemia and/or diabetes, but without cardiovascular disease, of the Japanese Primary Prevention Project to examine whether BP influenced the efficacy of low-dose acetylsalicylic acid for the primary prevention of cardiovascular events.

A total of 12,278 patients were assigned to aspirin (100 mg/day) or no aspirin and were further categorized into BP subgroups: low (average systolic BP form the baseline to the year of the events, <130 mm Hg), moderate (130 and <140 mm Hg) and high (≥140 mm Hg). Mean duration of follow-up was 5.02 years.

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Most Read Articles
Rachel Soon, 5 days ago

On 8 August, the first town hall held by the Ministry of Health (MOH) with members of the pharmacy profession took place in Putrajaya. Over 500 pharmacists from across the country and from different areas of practice—community and hospital, public and private, academy and industry—converged to fill the auditorium for the chance to engage in direct dialogue with MOH.

Jackey Suen, 08 Oct 2018

Adding pertuzumab to trastuzumab plus an aromatase inhibitor (AI) improves progression-free survival (PFS) in patients with HER2-positive metastatic or locally advanced breast cancer, the phase II PERTAIN study has shown.

05 Aug 2019
Use of alpha blockers in the treatment of hypertension in women is associated with an increased risk of hypotension and related events as compared with other blood pressure-lowering drugs, as reported in a recent study.
Laura Kho Sui San , 29 May 2019
Anxiety becomes a pathological disorder when it occurs for no detectable reason, persists and interferes with daily activities like work performance and relationships.