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Aspirin may avert glioma

18 Mar 2019

Aspirin use is associated with a lower risk of glioma, according to data from the Glioma International Case-Control Study (GICC).

GICC involved 4,533 glioma patients and 4,171 healthy controls who were then interviewed regarding their use of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs). Regular use was defined as use at least once per week for ≥6 months. Researchers applied restricted maximum likelihood meta-regression models to aggregate site-specific estimates and to combine GICC estimates with previously published studies.

A total of 1,641 participants were regular aspirin users: 764 (19.0 percent) glioma patients and 877 (22.7 percent) controls. Major indications included headaches, muscle/joint aches and cardioprevention. On the other hand, 542 (13.9 percent) patients and 533 (14.6 percent) controls reported regular NSAID use.

A history of daily aspirin use for ≥6 months was associated with a 38-percent decrease in the risk of glioma compared with nonuse (adjusted meta-odds ratio [mOR], 0.62; 95 percent CI, 0.54–0.70). Moreover, a significant duration-response trend was observed (p=1.67×10−17), with lower ORs for increasing duration of aspirin use. This trend was not seen for NSAID use.

In the meta-analysis pooling GICC data with five previous studies, a marginally significant association between use of aspirin and glioma emerged (mOR, 0.84; 0.70–1.02) but none for NSAID use.

Researchers noted that the reduced glioma risk associated with regular aspirin use is consistent with reports from previous studies, and that the duration-response trend observed provides a strong rationale for further investigation. [Eur J Epidemiol 2016;31:917-925; Int J Cancer 2012;131:E1031-E1037]

Further studies that utilize more comprehensive exposure assessment strategies and investigate each NSAID separately in order to account for differences in COX-2 selectivity or pharmacological properties are needed.

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Most Read Articles
Tristan Manalac, 5 days ago
Left ventricular assist devices (LVADs) can reverse pulmonary hypertension secondary to left heart disease regardless of baseline pulmonary vascular resistance, according to a new study.
11 May 2019
Acute kidney injury (AKI) commonly occurs within a year after cancer diagnosis in paediatric patients and is tied to long-term deteriorations in renal function, a recent study has found.
11 May 2019
Women practicing exclusive breastfeeding for 6 months achieve greater postpartum weight loss compared with those exclusively breastfeeding for a shorter duration, according to data from the MILK* study.
Pearl Toh, 13 May 2019
The selective cap-dependent endonuclease inhibitor baloxavir marboxil (hereafter baloxavir) effectively improves influenza symptoms in adolescent patients and those at high risk for influenza complications, according to two subanalyses of the CAPSTONE studies presented at ECCMID 2019.