Most Read Articles
21 Sep 2020
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Jairia Dela Cruz, 16 Sep 2020
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
Percutaneous coronary intervention (PCI), compared with coronary artery bypass grafting (CABG), in the revascularization of left main coronary artery (LMCA) disease may lead to death, myocardial infarction (MI), or stroke in patients with moderate or severe left ventricular (LV) dysfunction, reveals a study.

Aspirin may accelerate cancer progression in elderly patients

08 Sep 2020

Use of aspirin in older adults with cancer may do more harm than good, exerting an adverse effect on later stages of cancer evolution, as reported in a study.

Researchers conducted a more detailed analysis of the effect of aspirin on cancer incidence and mortality in ASPREE* participants. The analysis included 19,114 Australian and US community-dwelling participants aged 70 years without cardiovascular disease, dementia, or physical disability.

At baseline, 3,660 patients (19.1 percent) had a prior diagnosis of cancer. The compliance to study medication was 72.7 percent in the aspirin group and 74.5 percent in the placebo group. Over a median follow-up of 4.7 years, 981 individuals in the aspirin group and 952 in the placebo group developed cancer following randomization, regardless of whether they had a past cancer history at baseline.

Of the patients who developed new-onset cancer, 1,270 (65.7 percent) presented with localized tumour, 363 (18.8 percent) with new metastatic disease, 113 (5.8 percent) with metastatic disease of a cancer type already present before study entry, and 187 (9.7 percent) with a haematological or lymphatic cancer. A total of 495 patients (25.6 percent) died due to their malignancy, among whom 52 died from progression of a cancer initially diagnosed prior to trial entry.

In Cox proportional hazards models, aspirin had a null effect on the risk of first incident of cancer (hazard ratio [HR], 1.04, 95 percent confidence interval [CI], 0.95–1.14), haematological cancer (HR, 0.98, 95 percent CI, 0.73–1.30), or the overall incidence of solid cancers (HR, 1.05, 95 percent CI, 0.95–1.15).

However, aspirin use contributed to an increased risk of incident cancer that had metastasized (HR, 1.19, 95 percent CI, 1.00–1.43) or was stage 4 at diagnosis (HR, 1.22, 95 percent CI, 1.02–1.45) and to a higher risk of death for cancers that presented at stages 3 (HR, 2.11, 95 percent CI, 1.03–4.33) or 4 (HR, 1.31, 95 percent CI, 1.04–1.64).

Based on the present data, the researchers urged caution when considering aspirin in elderly cancer patients.

*ASPirin in Reducing Events in the Elderly

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Most Read Articles
21 Sep 2020
Chest pain appears to be the principal complaint of patients hospitalized with a first myocardial infarction (MI), particularly among those in the youngest age group, a study has found.
Jairia Dela Cruz, 16 Sep 2020
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
Percutaneous coronary intervention (PCI), compared with coronary artery bypass grafting (CABG), in the revascularization of left main coronary artery (LMCA) disease may lead to death, myocardial infarction (MI), or stroke in patients with moderate or severe left ventricular (LV) dysfunction, reveals a study.