Most Read Articles
Pearl Toh, 10 Oct 2019
Adding a LAMA* to the double combination therapy of ICS** plus LABA*** in a single inhaler improves lung function and reduces exacerbations in patients whose asthma is inadequately controlled with the combination treatment, according to the TRIMARAN and TRIGGER# studies presented at ERS 2019.
4 days ago
Eating alone may help in weight management as findings of a recent study suggest that eating with friends lead to higher food intake.
Tristan Manalac, 3 days ago
A digital-first approach, iConnect, allows patients to have greater access to services and guidance and enables healthcare providers to deliver much better postdischarge care, according to Lim Cher Wee, chief operating officer of the Ministry of Health, Office for Healthcare Transformation of Singapore, in his presentation at the recently concluded AsiaPac19 Conference & Exhibition of the Healthcare Information and Management Systems Society (HIMSS 2019).
Jairia Dela Cruz, 3 days ago
Toileting behaviours such as convenience and delayed voiding, straining to void, and position preference are strongly associated with overactive bladder (OAB) symptoms in women, according to a study.

Aspirin for primary prevention reduces ischaemic events but increases bleeding

19 Jun 2019
For nearly 100 years, aspirin has been a common drug used for pain relief and fever treatment.

Use of aspirin for primary prevention of cardiovascular (CV) events leads to lower nonfatal ischaemic events but significantly greater nonfatal bleeding events, a recent study has shown.

This analysis sought to examine the clinical outcomes with aspirin for primary prevention of CV disease after the recent publication of large trials adding >45,000 individuals to the published data. Included were randomized controlled trials (RCTs) comparing clinical outcomes with aspirin vs control with follow-up duration of at least 1 year.

Efficacy outcomes were as follows: all-cause death, CV death, myocardial infarction (MI), stroke, transient ischaemic attack (TIA) and major adverse CV events. Safety outcomes were major bleeding, intracranial bleeding, fatal bleeding and major gastrointestinal (GI) bleeding. The investigators calculated random effects DerSimonian-Laird risk ratios (RRs) for outcomes.

Fifteen RCTs involving a total of 165,502 participants (aspirin, n=83,529; control, n=81,973) were included in the analysis.

Aspirin, compared with control, correlated with similar all-cause death (RR, 0.97, 95 percent CI, 0.93–1.01), CV death (RR, 0.93, 0.86–1.00) and non-CV death (RR, 0.98, 0.92–1.05) but reduced risks of nonfatal MI (RR, 0.82, 0.72–0.94), TIA (RR, 0.79, 0.71–0.89) and ischaemic stroke (RR, 0.87, 0.79–0.95).

Aspirin users also had a higher risk of major bleeding (RR, 1.5, 1.33–1.69), intracranial bleeding (RR, 1.32, 1.12–1.55) and major GI bleeding (RR, 1.52, 1.34–1.73), with similar rates of fatal bleeding (RR, 1.09, 0.78–1.55) compared with controls. Within the follow-up period of the study, both groups had comparable total cancer and cancer-related deaths.

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Most Read Articles
Pearl Toh, 10 Oct 2019
Adding a LAMA* to the double combination therapy of ICS** plus LABA*** in a single inhaler improves lung function and reduces exacerbations in patients whose asthma is inadequately controlled with the combination treatment, according to the TRIMARAN and TRIGGER# studies presented at ERS 2019.
4 days ago
Eating alone may help in weight management as findings of a recent study suggest that eating with friends lead to higher food intake.
Tristan Manalac, 3 days ago
A digital-first approach, iConnect, allows patients to have greater access to services and guidance and enables healthcare providers to deliver much better postdischarge care, according to Lim Cher Wee, chief operating officer of the Ministry of Health, Office for Healthcare Transformation of Singapore, in his presentation at the recently concluded AsiaPac19 Conference & Exhibition of the Healthcare Information and Management Systems Society (HIMSS 2019).
Jairia Dela Cruz, 3 days ago
Toileting behaviours such as convenience and delayed voiding, straining to void, and position preference are strongly associated with overactive bladder (OAB) symptoms in women, according to a study.