Most Read Articles
Pearl Toh, 6 days ago
Adding a LAMA* to the double combination therapy of ICS** plus LABA*** in a single inhaler improves lung function and reduces exacerbations in patients whose asthma is inadequately controlled with the combination treatment, according to the TRIMARAN and TRIGGER# studies presented at ERS 2019.
5 days ago
Transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) have comparable safety in low-risk surgical patients, reports a new meta-analysis.
3 days ago
Eating alone may help in weight management as findings of a recent study suggest that eating with friends lead to higher food intake.
Tristan Manalac, 2 days ago
A digital-first approach, iConnect, allows patients to have greater access to services and guidance and enables healthcare providers to deliver much better postdischarge care, according to Lim Cher Wee, chief operating officer of the Ministry of Health, Office for Healthcare Transformation of Singapore, in his presentation at the recently concluded AsiaPac19 Conference & Exhibition of the Healthcare Information and Management Systems Society (HIMSS 2019).

Aspirin, rivaroxaban similarly effective for preventing venous thromboembolism

21 Mar 2018

Aspirin is as effective as rivaroxaban in the prevention of symptomatic venous thromboembolism following total hip or total knee arthroplasty in patients who have already received 5 days of rivaroxaban prophylaxis, according to a study.

A total of 3,424 patients who underwent total hip or knee arthroplasty received once-daily oral rivaroxaban (10 mg) until postoperative day 5, and were then randomly assigned to either continue rivaroxaban or switch to aspirin (81 mg) for 9 days in the total knee arthroplasty group (n=1,620) or for 30 days in the total hip arthroplasty group (n=1,804).

All patients were followed for 90 days for symptomatic venous thromboembolism (main efficacy outcome) and bleeding complications, including major or clinically relevant nonmajor bleeding (main safety outcome).

Venous thromboembolism occurred in 11 of 1,707 patients (0.64 percent) who received aspirin vs 12 of 1,717 patients (0.70 percent) who received rivaroxaban (difference, 0.06 percentage points; 95 percent CI, −0.55 to 0.66; p<0.001 for noninferiority and p=0.84 for superiority).

Major bleeding complications were documented in eight patients (0.47 percent) on aspirin vs five patients (0.29 percent) on rivaroxaban (difference, 0.18 percentage points; −0.65 to 0.29; p=0.42).

Clinically important bleeding occurred in 22 patients (1.29 percent) on aspirin vs 17 patients (0.99 percent) on rivaroxaban (difference, 0.30 percentage points; −1.07 to 0.47; p=0.43).

Deep-vein thrombosis and pulmonary embolism (collectively called venous thromboembolism) are known complications after total hip or total knee arthroplasty. The perioperative administration of anticoagulant prophylaxis has been shown to effectively reduce the rates of death and complications associated with venous thromboembolism after such procedures. Aspirin, an inexpensive and widely available antiplatelet drug, has also been shown to be effective in the postoperative prevention of venous thromboembolism. [Chest 2008;133:381S-453S; Arch Intern Med 2003;163:1362-1366]

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 6 days ago
Adding a LAMA* to the double combination therapy of ICS** plus LABA*** in a single inhaler improves lung function and reduces exacerbations in patients whose asthma is inadequately controlled with the combination treatment, according to the TRIMARAN and TRIGGER# studies presented at ERS 2019.
5 days ago
Transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) have comparable safety in low-risk surgical patients, reports a new meta-analysis.
3 days ago
Eating alone may help in weight management as findings of a recent study suggest that eating with friends lead to higher food intake.
Tristan Manalac, 2 days ago
A digital-first approach, iConnect, allows patients to have greater access to services and guidance and enables healthcare providers to deliver much better postdischarge care, according to Lim Cher Wee, chief operating officer of the Ministry of Health, Office for Healthcare Transformation of Singapore, in his presentation at the recently concluded AsiaPac19 Conference & Exhibition of the Healthcare Information and Management Systems Society (HIMSS 2019).