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ASAS Health Index a useful tool for evaluating spondyloarthritis in daily practice

29 Oct 2020

A recent study has demonstrated the effectiveness of the Assessment of SpondyloArthritis international Society Health Index (ASAS HI) in the evaluation of spondyloarthritis (SpA) in daily practice.

“Given its good clinimetric properties, it could be used as an additional instrument to evaluate SpA,” the investigators said.

A total of 111 consecutive patients with SpA were included in this cross-sectional study, in which the measurement properties of ASAS HI were tested against conventional assessment measures. The investigators assessed convergent validity using Spearman rho correlations and analysed discriminative validity through receiver-operating characteristic (ROC) curves. ASAS HI items associated with active disease were identified by performing a multivariate regression analysis.

The average ASAS HI was 5.4±3.8 (interquartile range, 3–8). This tool demonstrated high convergent validity against other measures of SpA (rho ≥0.70; p<0.0005). An ASAS HI score of >6 (area under the ROC curve 0.86, 95 percent confidence interval [CI], 0.78–0.92, positive likelihood ratio, 7.3, 95 percent CI, 3.1–17.1; p<0.0001) was the optimal criteria for detecting high/very high disease activity Ankylosing Spondylitis Disease Activity Score (ASDAS) categories.

The following ASAS HI items significantly correlated with Bath Ankylosing Spondylitis Disease Activity Index active disease: “I often get frustrated” (odds ratio [OR], 9.2, 95 percent CI, 1.2–69.4; p=0.032) and “I sleep badly at night” (OR, 7.7, 95 percent CI, 1.4–41.6; p=0.018). For ASDAS, the item correlate was “Pain sometimes disrupts my normal activities” (OR, 8.7, 95 percent CI, 1.7–45.2; p=0.010).

ASAS HI is a useful and simple instrument designed to assess disease impact in SpA.

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Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).