Most Read Articles
11 May 2020
This second issue revisits the impact EMPA-REG OUTCOME had on clinical practice and helps readers discover how it gives life back to patients through its cardiovascular indication. Learn how it was approved and the possible mechanisms for its cardiovascular benefits.
Pearl Toh, 15 Oct 2020
Cycling was associated with reduced risk for both all-cause and cardiovascular (CV) mortality in people with diabetes, according to a study presented at EASD 2020 Meeting — suggesting that cycling could be encouraged as an activity to prevent deaths in this population who are known to have a higher mortality risk than the general public.
Stephen Padilla, 22 Jul 2019
Zinc supplementation significantly lowers key glycaemic indicators, particularly fasting glucose (FG) in individuals with diabetes and in those who received an inorganic supplement, results of a systematic review and meta-analysis have shown.
Elaine Soliven, 15 Oct 2020

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.

Arterial stiffness tied to clinical outcome, cardiorenal Injury in lateralized primary aldosteronism

03 Oct 2020

An association exists between preoperative severe arterial stiffness and absence of complete clinical success in lateralized primary aldosteronism (PA) patients following adrenalectomy, a study has found. Such effect may play a role in cardiorenal injury, which partially explains kidney function deterioration and reduced regression of heart mass.

The investigators hypothesized that arterial stiffness estimated by brachial-ankle pulse wave velocity (baPWV) before adrenalectomy was associated with the clinical outcomes and cardiorenal injury in lateralized PA patients after adrenalectomy.

To test this hypothesis, they carried out a retrospective observational cohort study and included lateralized PA patients who had undergone adrenalectomy between 2013 and 2016 from the Taiwan Primary Aldosteronism Investigation database.

Complete clinical success at 1 year after adrenalectomy was the primary outcome. The secondary outcome was estimated glomerular filtration rate declining over 20 percent and improved left ventricular mass index.

Of the 221 patients with lateralized PA (mean age, 51.9 years; 50.7 percent men) included, 101 (45.7 percent) achieved complete clinical success at the 1-year follow-up assessment after adrenalectomy. In multivariate logistic regression analysis, lower baPWV before adrenalectomy was associated with higher likelihood of complete clinical success (odds ratio, 0.998, 95 percent confidence interval, 0.996–0.999; p=0.003).

Preoperative baPWV <1,600 cm/sec significantly correlated with complete cure of hypertension in multifactorial adjusted generalized additive model. Additionally, higher preoperative baPWV correlated with renal function decline and less left ventricular mass regression after adrenalectomy in lateralized PA patients during the follow-up period.

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Most Read Articles
11 May 2020
This second issue revisits the impact EMPA-REG OUTCOME had on clinical practice and helps readers discover how it gives life back to patients through its cardiovascular indication. Learn how it was approved and the possible mechanisms for its cardiovascular benefits.
Pearl Toh, 15 Oct 2020
Cycling was associated with reduced risk for both all-cause and cardiovascular (CV) mortality in people with diabetes, according to a study presented at EASD 2020 Meeting — suggesting that cycling could be encouraged as an activity to prevent deaths in this population who are known to have a higher mortality risk than the general public.
Stephen Padilla, 22 Jul 2019
Zinc supplementation significantly lowers key glycaemic indicators, particularly fasting glucose (FG) in individuals with diabetes and in those who received an inorganic supplement, results of a systematic review and meta-analysis have shown.
Elaine Soliven, 15 Oct 2020

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.