Most Read Articles
Rachel Soon, 26 Jun 2018

MIMS Pharmacist presents an overview of phosphatidylcholine's physiological role, as well as contemporary research on its pharmacology and effects.

17 Mar 2018
Nonvitamin K antagonist oral anticoagulants (NOAC)-associated intracerebral haemorrhage (ICH) and vitamin K antagonists-ICH appear to have similar ICH volume, haematoma expansion, functional outcome and mortality, results of a recent meta-analysis have shown.
31 May 2017
New drug applications approved by US FDA as of 16 - 31 May 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
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Arterial stiffness predicts stroke in patients with essential hypertension

12 Jun 2018

Arterial stiffness is an independent predictor of stroke in patients with essential hypertension, a Greek 8-year follow-up study has shown.

The study included 1,079 patients with essential hypertension (mean age, 55.8 years; office blood pressure [BP], 144/91 mm Hg). Arterial stiffness was evaluated by carotid to femoral pulse wave velocity (PWV) using a computerized method, with patients classified into high (n=546) and low (533) PWV values based on the median of 8.1 m/sec. [Tsioufis KP, et al, ACC 2018, abstract 1170-424]

The incidence of stroke was 2.03 percent over the follow-up period. Compared with patients without stroke, those with stroke were older at baseline (age, 63 vs 55 years; p=0.012), had higher office systolic BP (155 vs 144 mm Hg; p=0.022), and more commonly had high PWV values (68 percent vs 42 percent; p=0.019). No significant difference was observed between patients with and without stroke with respect to baseline renal function and lipid levels.

PWV (hazard ratio [HR], 1.105; p=0.015) and baseline age (HR, 1.098; p=0.04), but not baseline office BP, were found to be independent predictors of stroke on multivariate Cox regression analysis.

According to the researchers, the findings support PWV as a potent prognosticator of cerebrovascular events in patients with essential hypertension. “PWV estimation is essential to improve risk stratification in hypertension,” they suggested.

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Most Read Articles
Rachel Soon, 26 Jun 2018

MIMS Pharmacist presents an overview of phosphatidylcholine's physiological role, as well as contemporary research on its pharmacology and effects.

17 Mar 2018
Nonvitamin K antagonist oral anticoagulants (NOAC)-associated intracerebral haemorrhage (ICH) and vitamin K antagonists-ICH appear to have similar ICH volume, haematoma expansion, functional outcome and mortality, results of a recent meta-analysis have shown.
31 May 2017
New drug applications approved by US FDA as of 16 - 31 May 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
09 Dec 2017
Intravenous (IV) iron is less toxic and more effective compared to oral iron, making it a potential frontline therapy for neonatal iron deficiency anaemia, suggests a recent study.