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Prof. Cheuk-Chun Szeto, Dr. Winston W. S. Fung, 25 Jan 2018
A 65-year-old lady with a background of type 2 diabetes, hyperlipidaemia and chronic immune thrombocytopenia presented to us with a 2-week history of generalized malaise and myalgia. Shortly after the onset of myalgia, she was noted to have reduced urine output and the urine was described as dark in colour. Her regular medications included prednisolone, danazol, simvastatin, metformin, and human insulin. Upon further questioning, the patient admitted that her compliance to simvastatin and danazol used to be poor. However, she recently started to take both medications regularly after repeated education.
Pearl Toh, 30 Jan 2018
Use of statins may not be neuroprotective, in contrast to findings from previous observational studies. On the contrary, fungus-derived or lipophilic statins appeared to be associated with a slightly increased risk of Alzheimer's disease (AD) compared with synthetic and hydrophilic statins, suggests a new study based on real-world clinical practice data.
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Hoo Yee Yin, 05 Jun 2018
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Arterial stiffness predicts stroke in patients with essential hypertension

12 Jun 2018

Arterial stiffness is an independent predictor of stroke in patients with essential hypertension, a Greek 8-year follow-up study has shown.

The study included 1,079 patients with essential hypertension (mean age, 55.8 years; office blood pressure [BP], 144/91 mm Hg). Arterial stiffness was evaluated by carotid to femoral pulse wave velocity (PWV) using a computerized method, with patients classified into high (n=546) and low (533) PWV values based on the median of 8.1 m/sec. [Tsioufis KP, et al, ACC 2018, abstract 1170-424]

The incidence of stroke was 2.03 percent over the follow-up period. Compared with patients without stroke, those with stroke were older at baseline (age, 63 vs 55 years; p=0.012), had higher office systolic BP (155 vs 144 mm Hg; p=0.022), and more commonly had high PWV values (68 percent vs 42 percent; p=0.019). No significant difference was observed between patients with and without stroke with respect to baseline renal function and lipid levels.

PWV (hazard ratio [HR], 1.105; p=0.015) and baseline age (HR, 1.098; p=0.04), but not baseline office BP, were found to be independent predictors of stroke on multivariate Cox regression analysis.

According to the researchers, the findings support PWV as a potent prognosticator of cerebrovascular events in patients with essential hypertension. “PWV estimation is essential to improve risk stratification in hypertension,” they suggested.

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Most Read Articles
Prof. Cheuk-Chun Szeto, Dr. Winston W. S. Fung, 25 Jan 2018
A 65-year-old lady with a background of type 2 diabetes, hyperlipidaemia and chronic immune thrombocytopenia presented to us with a 2-week history of generalized malaise and myalgia. Shortly after the onset of myalgia, she was noted to have reduced urine output and the urine was described as dark in colour. Her regular medications included prednisolone, danazol, simvastatin, metformin, and human insulin. Upon further questioning, the patient admitted that her compliance to simvastatin and danazol used to be poor. However, she recently started to take both medications regularly after repeated education.
Pearl Toh, 30 Jan 2018
Use of statins may not be neuroprotective, in contrast to findings from previous observational studies. On the contrary, fungus-derived or lipophilic statins appeared to be associated with a slightly increased risk of Alzheimer's disease (AD) compared with synthetic and hydrophilic statins, suggests a new study based on real-world clinical practice data.
26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
Hoo Yee Yin, 05 Jun 2018
Enteral nutrition (EN) is also known as tube feeding. It is nutrition provided through the gastrointestinal (GI) tract via a tube, catheter, or stoma that delivers nutrients distal to the oral cavity.