Most Read Articles
Jairia Dela Cruz, 4 days ago
The potassium-competitive acid blocker vonoprazan demonstrates superior efficacy in the treatment of patients with erosive oesophagitis compared with the proton pump inhibitor lansoprazole, with the results of a small trial showing that the former more rapidly provides complete sustained heartburn relief during the first week of therapy.
01 Mar 2016
Bathing with 2% chlorhexidine gluconate-medicated washcloth is cost-effective for the prevention of central line-associated bloodstream infection (CLABSI), based on a systematic review and meta-analysis of four studies.
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Tacrolimus is safe and effective in inducing and maintaining remission in paediatric patients with biologic refractory inflammatory bowel disease (IBD), according to a study presented at the 49th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition in Athens, Greece.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.

Arterial stiffness predicts stroke in patients with essential hypertension

12 Jun 2018

Arterial stiffness is an independent predictor of stroke in patients with essential hypertension, a Greek 8-year follow-up study has shown.

The study included 1,079 patients with essential hypertension (mean age, 55.8 years; office blood pressure [BP], 144/91 mm Hg). Arterial stiffness was evaluated by carotid to femoral pulse wave velocity (PWV) using a computerized method, with patients classified into high (n=546) and low (533) PWV values based on the median of 8.1 m/sec. [Tsioufis KP, et al, ACC 2018, abstract 1170-424]

The incidence of stroke was 2.03 percent over the follow-up period. Compared with patients without stroke, those with stroke were older at baseline (age, 63 vs 55 years; p=0.012), had higher office systolic BP (155 vs 144 mm Hg; p=0.022), and more commonly had high PWV values (68 percent vs 42 percent; p=0.019). No significant difference was observed between patients with and without stroke with respect to baseline renal function and lipid levels.

PWV (hazard ratio [HR], 1.105; p=0.015) and baseline age (HR, 1.098; p=0.04), but not baseline office BP, were found to be independent predictors of stroke on multivariate Cox regression analysis.

According to the researchers, the findings support PWV as a potent prognosticator of cerebrovascular events in patients with essential hypertension. “PWV estimation is essential to improve risk stratification in hypertension,” they suggested.

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Most Read Articles
Jairia Dela Cruz, 4 days ago
The potassium-competitive acid blocker vonoprazan demonstrates superior efficacy in the treatment of patients with erosive oesophagitis compared with the proton pump inhibitor lansoprazole, with the results of a small trial showing that the former more rapidly provides complete sustained heartburn relief during the first week of therapy.
01 Mar 2016
Bathing with 2% chlorhexidine gluconate-medicated washcloth is cost-effective for the prevention of central line-associated bloodstream infection (CLABSI), based on a systematic review and meta-analysis of four studies.
31 May 2016
Tacrolimus is safe and effective in inducing and maintaining remission in paediatric patients with biologic refractory inflammatory bowel disease (IBD), according to a study presented at the 49th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition in Athens, Greece.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.