Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Arrhythmias common in maintenance dialysis patients

12 Oct 2019

Arrhythmias, including clinically significant abnormal rhythms, occur commonly in patients undergoing maintenance dialysis, a study has found. Furthermore, tachyarrhythmias are more frequent during dialysis and the immediate postdialytic period.

The cross-sectional study included 152 kidney failure patients receiving maintenance dialysis: 83.6 percent in-centre, 10.5 percent home haemodialysis and 5.9 percent peritoneal dialysis. Researchers determined the prevalence and pattern of arrhythmias using 48-hour Holter monitoring, and defined cardiac output and preload using echocardiography.

Nearly all patients presented with premature atrial and ventricular complexes, and 41 percent had paroxysmal supraventricular tachycardia. Clinically significant arrhythmias included persistent atrial fibrillation seen in 8.6 percent of patients, paroxysmal atrial fibrillation in 3.9 percent, nonsustained ventricular tachycardia in 19.7 percent, bradycardia in 4.6 percent, advanced second-degree atrioventricular block in 1.3 percent and third-degree atrioventricular block in 2.6 percent.

Premature ventricular complexes were more common on dialysis days, while tachyarrhythmias were more often observed during dialysis and in the immediate postdialytic period.

Logistic regression analysis revealed that clinically significant arrhythmias were associated with older age (odds ratio [OR] per 10 years older, 1.53, 95 percent CI, 1.15–2.03; p=0.003), elevated preload (OR, 4.02, 1.05–15.35; p=0.04), and lower cardiac output (OR per 1 L/min increase, 0.66; 95% CI, 0.44-1.00; P = 0.05).

The study was limited by reduced duration of arrhythmia monitoring, a small sample size, the heterogeneous nature of the population and risk for residual confounding.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.