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Aronia berries improve vascular function, modulates gut microbiota in men

08 Aug 2019

Consumption of aronia berry polyphenols enhances endothelial function and regulates gut microbiota composition in men, reports a study. This shows that eating aronia berries regularly may help maintain cardiovascular health in individuals at low risk of cardiovascular disease (CVD).

This double-blind, placebo-controlled, parallel study randomized 66 healthy men to consume a polyphenol-rich extract (116 mg, 75 g berries), a whole fruit powder (12 mg, 10 g berries) or placebo (maltodextrin) for 12 weeks.

The investigators assessed flow-mediated dilation (FMD), arterial stiffness, blood pressure, heart rate and serum biochemistry. Liquid chromatography–mass spectrometry was used to analyse plasma polyphenol metabolites. Gut microbiota composition was determined through 16s rRNA sequencing in stool samples.

FMD significantly increased with the consumption of aronia whole fruit (0.9±0.4 percent, 95 percent CI, 0.13–1.72 percent) and extract powder (1.2±0.4 percent, 0.36–1.97 percent) for 12 weeks. There were also acute improvements in FMD 2 hours after aronia extract consumption on day 1 (1.1±0.3 percent; p=0.003) and 12 weeks later (1.5±0.4 percent; p=0.0001).

Consumption of aronia in any form led to an increase in circulating plasma phenolic metabolites. There were no changes seen in gut microbiota diversity, but aronia extract increased the growth of Anaerostipes (10.6 percent; p=0.01), whereas aronia whole fruit showed significant increases in Bacteroides (193 percent; p=0.01).

In correlation analysis, significant associations were found between changes in FMD, aronia-derived phenolic metabolites and specific gut microbial genera.

Aronia melanocarpa is a rich source of polyphenols,” the authors said. “Previous research has demonstrated that these berries may provide cardiovascular health benefits in high-risk populations.”

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Most Read Articles
6 days ago
Chest pain appears to be the principal complaint of patients hospitalized with a first myocardial infarction (MI), particularly among those in the youngest age group, a study has found.
Jairia Dela Cruz, 16 Sep 2020
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 6 days ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Yesterday
Percutaneous coronary intervention (PCI), compared with coronary artery bypass grafting (CABG), in the revascularization of left main coronary artery (LMCA) disease may lead to death, myocardial infarction (MI), or stroke in patients with moderate or severe left ventricular (LV) dysfunction, reveals a study.