Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).

ARIC study: Stay active, save the kidneys

11 Oct 2020

Being physically active boosts health, and a recent study reports that moving more may reduce the risk of developing chronic kidney disease.

The study included 14,537 individuals aged 45–64 years from the Atherosclerosis Risk in Communities (ARIC) Study. Based on the modified Baecke Physical Activity Questionnaire, 37.8 percent of the participants were inactive at baseline, 24.2 percent were insufficiently active, 22.7 percent were active, and 15.3 percent were highly active.

Over a median follow-up of 24 years, CKD (defined as estimated glomerular filtration rate [eGFR] <60 mL/min/1.73 m2 at follow up and ≥25-percent decline in eGFR relative to baseline, CKD-related hospitalization or death, or end stage renal disease) occurred in 33.2 percent of participants.

Cox proportional hazards regression revealed a protective association between physical activity and CKD risk. Compared with inactive participants, those highly active had an 11-percent lower risk (hazard ratio [HR], 0.89, 95 percent confidence interval [CI], 0.81–0.97; ptrend=0.007), those active had a 7-percent lower risk (HR, 0.93, 95 percent CI, 0.86–1.01), and those insufficiently active had a 5-percent lower risk (HR, 0.95, 95 percent CI, 0.88–1.02).

The estimates were controlled for age, sex, race, education, smoking status, diet quality, diabetes, coronary heart disease, hypertension, antihypertensive medication, body mass index, and baseline eGFR.

There were several study limitations, including its observational design and self-reported physical activity that was based on leisure time activity only. Also, white and nonblack participants were excluded.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).