Most Read Articles
4 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Tristan Manalac, 3 days ago
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.
Dr. Wong Soon Tee, 18 hours ago
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.
Yesterday
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.

Arginine supplements effective for erectile dysfunction

28 Feb 2019
Sexual health in men – supplements vs medication

Arginine supplements appear to be an effective intervention for mild-to-moderate erectile dysfunction (ED), a recent meta-analysis has shown.

Applying the selection criteria resulted in 10 randomized controlled trials (RCTs) eligible for inclusion, corresponding to 540 patients with ED. All studies investigated the efficacy of arginine either alone or in combination with yohimbine, pycnogenol, ornithine or adenosine monophosphate. Treatment durations were at least 2 weeks.

Pooled analysis of six studies (n=309) showed that arginine supplements led to a significantly greater improvement in ED than placebo or no treatment (odds ratio [OR], 5.73; 95 percent CI, 2.02–16.23; p=0.0001). The effect remained significant even when arginine was taken alone (OR, 3.37; 1.28–8.77; p=0.01) or in combination with other supplements (OR, 18.93; 1.62–212.21; p=0.02).

In terms of secondary outcomes, researchers reported a significant improvement in the overall satisfaction scores in the International Index of Erectile Function associated with arginine use (weighted mean difference [WMD], 0.57; 0.30–0.84; p<0.0001), either alone (WMD, 0.37; 0.07–0.68; p=0.02) or in combination with other supplements (WMD, 1.22; 0.65–1.79; p<00001).

Similarly, significant improvements with arginine use were observed for orgasmic function (WMD, 1.02; 0.29–1.74; p=0.0060), erectile function (WMD, 4.39; 0.75–8.02; p=0.02) and intercourse satisfaction (WMD, 1.07; 0.32–1.83; p=0.005), but not for sexual desire (WMD, 0.63; –0.42 to 1.68; p=0.24).

Adverse events occurred in 8.3 percent of patients taking arginine and in 2.4 percent of those who received placebo. Common adverse events included headache, itching and insomnia. No severe adverse events were reported.

Editor's Recommendations
Most Read Articles
4 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Tristan Manalac, 3 days ago
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.
Dr. Wong Soon Tee, 18 hours ago
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.
Yesterday
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.