Most Read Articles
06 Jul 2020
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Jairia Dela Cruz, 06 Jul 2020
Following vegan and vegetarian diets, which offer plenty of what is good for health, has been reported to have a downside: an increased risk of depression and anxiety, especially for younger adults.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
Roshini Claire Anthony, 5 days ago

Upadacitinib may be a suitable treatment for patients with active psoriatic arthritis (PsA) who have insufficient response to non-biologic disease-modifying anti-rheumatic drugs (non-bDMARDs), according to results of the phase III SELECT-PsA-1* trial presented at EULAR 2020.

Apremilast effective for scalp psoriasis

17 Jun 2020
Psoriasis of the scalp

Apremilast is an effective treatment option for moderate-to-severe psoriasis of the scalp, a new trial has found.

The phase IIIb, double-blind, placebo-controlled trial included 252 patients who were randomly assigned to receive apremilast (n=168) or placebo (n=84). Only those with moderate-to-severe disease who showed inadequate response to at least one prior therapy were eligible. The primary efficacy endpoint was the proportion of patients showing Scalp Physician Global Assessment (ScPGA) response.

After 16 weeks of treatment, significantly more patients in the apremilast group achieved the primary endpoint relative to the placebo comparators (43.3 percent vs 13.7 percent; adjusted difference, 29.6 percent, 95 percent confidence interval [CI], 19.5–39.7; p<0.0001). Apremilast was given as 30-mg, twice-daily doses.

The comparative advantage of apremilast over placebo emerged as early as week 2 and was retained at all time points through week 16.

Moreover, a significantly greater proportion of apremilast vs placebo patients achieved a 4-point improvement on the scalp itch numerical rating scale (NRS; 47.1 percent vs 21.1 percent; p<0.0001). Change was assessed relative to baseline values. The same was true for whole body itch NRS (45.5 percent vs 22.5 percent; p<0.0001).

A total of 302 patients were given at least one dose of the study medication and were thus included in the safety analysis. The most common adverse events (AEs) in the apremilast group were diarrhoea, nausea, headache, and vomiting, all of which occurred substantially more frequently than in placebo counterparts.

Two patients in the apremilast group had serious AEs, five had severe AEs, and 11 experienced AEs that led to drug withdrawal.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
06 Jul 2020
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Jairia Dela Cruz, 06 Jul 2020
Following vegan and vegetarian diets, which offer plenty of what is good for health, has been reported to have a downside: an increased risk of depression and anxiety, especially for younger adults.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
Roshini Claire Anthony, 5 days ago

Upadacitinib may be a suitable treatment for patients with active psoriatic arthritis (PsA) who have insufficient response to non-biologic disease-modifying anti-rheumatic drugs (non-bDMARDs), according to results of the phase III SELECT-PsA-1* trial presented at EULAR 2020.