Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Pearl Toh, 6 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Elvira Manzano, 17 Nov 2020
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.

Apathy mediates treatment efficacy against cancer-related fatigue

04 Sep 2020

Patient apathy appears to be an important factor in determining the efficacy of interventions targeting cancer-related fatigue (CRF), reports a new study.

Researchers conducted a retrospective analysis of 213 cancer patients (mean age, 57.59±28.67 years; 64 percent female), in whom CRF was measured using the Brief Fatigue Inventory (BFI), while apathy was assessed using the Apathy Evaluation Scale (AES). Other symptoms included pain intensity, depression, anxiety, stress, and sleepiness.

Most of the patients (54 percent) reported starting to feel fatigue during treatment; according to physician assessments, only 13 percent of the patients had fatigue that was likely unrelated to cancer or treatment. Fatigue severity was 6.24±1.94 at the time of consult and dropped to 5.04±2.36 at follow-up.

Improvement in fatigue correlated significantly with improvements in apathy, depression, stress, pain, sleepiness, and anxiety (p<0.001 for all).

The most common type of treatment prescribed was psychostimulants and wakefulness agents, reported in 26 percent (n=56) of the participants. Linear models found that a psychostimulant-based regimen led to significant drops in fatigue.

Apathy also emerged as an important correlate. The use of psychostimulants led to a significant reduction in apathy (B, –3.15±1.25; p=0.012), but not in pain, sleepiness, anxiety, or other emotional symptoms.

Notably, researchers found that including apathy in the model for fatigue weakened the impact of psychostimulant use. This suggested that the beneficial effect of medication was at least in part mediated by a reduction in apathy. Patients with lower apathy were also more likely to initiate or increase physical activity following the consult (p=0.04).

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Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Pearl Toh, 6 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Elvira Manzano, 17 Nov 2020
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.