Most Read Articles
3 days ago
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Roshini Claire Anthony, 13 Nov 2020

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Tristan Manalac, 6 days ago
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).

Aortic bioprosthetic leaflet calcification tied to haemodynamic valve deterioration, death risk

18 Oct 2020

Bioprosthetic aortic valve leaflet calcification shows a robust and independent association with haemodynamic valve deterioration (HVD) and the risk of death or aortic valve reintervention (AVR), suggests a study. No sex-related difference exists in the link between aortic valve calcification (AVC) density and haemodynamic or clinical outcomes as opposed to native aortic stenosis.

The authors prospectively enrolled 204 patients from 2008 to 2010, with a median of 7.0 years (interquartile range, 5.1–9.2 years) after biological surgical AVR. AVC density was calculated by indexing AVC (measured using the Agatston method) to the cross-sectional area of aortic annulus (measured by echocardiography).

At 3-year follow-up, the authors assessed the presence of HVD (increase in mean gradient [MG] ≥10 mm Hg and/or increase in transprosthetic regurgitation ≥1) by echocardiography in 137 patients. Mortality or AVR was the primary clinical endpoint.

No significant sex-related difference was found in the relationship between bioprosthetic AVC density and MG progression. At 3 years, baseline AVC density was independently associated with HVD. A total of 134 (65.7 percent) deaths (n=100) or valve reintervention (n=47) occurred during follow-up.

Of note, AVC density ≥58 AU/cm2 independently correlated with a higher risk of mortality or AVR (adjusted hazard ratio, 2.23, 95 percent confidence interval, 1.44–3.35; p<0.001).

Stratification of at-risk patients was amplified by the AVC density threshold combined with an MG progression threshold (log-rank; p<0.001). The addition of AVC density threshold to the prediction model including traditional risk factors improved outcome prediction (net classification improvement, 0.25; p=0.04; likelihood ratio test, p<0.001).

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Most Read Articles
3 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
2 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 6 days ago
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).