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Anxiety disorder associated with higher risk of osteoporosis

16 Nov 2016

People with a history of anxiety disorder are more likely to have osteoporosis, according to a Taiwan study presented at the International Osteoporosis Foundation (IOF) Regionals 2016.

“The risk ratios (RRs) are the highest for osteoporosis within 1 year of anxiety disorder diagnosis, but the risk remains statistically significant for more than 1 year,” researchers said.

Using data in the Longitudinal Health Insurance Database 2000 of Taiwan, a population-based retrospective cohort analysis was conducted to assess the association between anxiety disorder and the subsequent development of osteoporosis. Included were 7,098 patients in both the anxiety disorder and no-anxiety groups who were matched according to age and sex between 2000 and 2013.

Researchers calculated the incidence rate and RRs of subsequent new-onset osteoporosis for both cohorts. Cox proportional hazards models were used to assess the effect of anxiety disorder, and the Kaplan-Meier method was applied to estimate the cumulative osteoporosis incidence curves.

Patients in the anxiety disorder cohort had a higher risk of osteoporosis than those in the comparison cohort. In addition, the incidence of newly diagnosed osteoporosis remained significantly increased in all of the stratified follow-up durations (0 to 1, 1 to 5, 5 to 10, ≥10 years).

Patients with anxiety disorder were 1.79 times more likely to get osteoporosis than those without. There was also a significant increase in osteoporotic risk in patients with anxiety disorder who were comorbid with hypertension, diabetes mellitus and chronic liver disease.

Researchers suggested that clinicians should pay particular attention to osteoporotic comorbidities in patients with anxiety disorder.

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