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Antiviral therapy improves surgery-free survival in UC patients

10 Apr 2018

Antiviral treatment for colonic cytomegalovirus (CMV) infection significantly improves short- and long-term surgery-free survival in patients with ulcerative colitis (UC), according to the results of a small-scale study.

Patients in treated and nontreated groups had similar demographic variables. Patients who received antiviral therapy had significantly improved surgery-free survival within 30 days and lasted 70 months (p<0.01).

On the other hand, both treated and nontreated groups showed similar rates of hospitalization, rehospitalization and mortality (p>0.05). Furthermore, there was no significant between-group difference in any of the clinical outcomes based on viremia status.

In total, 1,478 patients who had colon biopsy and were tested for CMV during 1990–2013 were identified from the Cleveland Clinic pathology database. Forty-one UC patients were selected after inclusion and exclusion, of whom 24 (58.5 percent) received treatment and 17 (41.5 percent) did not.

The authors compared 14 demographic data and four clinical outcomes (surgery-free survival, hospitalization, rehospitalization and mortality) between treated and nontreated patients. They also compared the same outcomes in patients who received treatment based on their viremia status.

“The frequency of CMV colitis in steroid-refractory inflammatory bowel disease has been reported to range from 15.8–34.0 percent. Infected patients are more likely to become hospitalized, have longer lengths of stay and higher mortality rates,” the authors said.

“Current data are limited to small scale studies and showed conflicting result regarding the role of antiviral therapy,” they added.

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Most Read Articles
18 Apr 2018
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 6 days ago
Infants delivered via caesarean section may be at increased risk of developing acute lymphoblastic leukaemia, according to a US study. Altered microbiota colonization is a possible explanation for this risk, although clear biological mechanisms have yet to be established.
5 days ago
Treatment with danegaptide does not improve myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention, according to the results of a phase II study.
Pearl Toh, 3 days ago
Tai Chi may be equivalent to pulmonary rehabilitation (PR) in improving health status of patients with chronic obstructive pulmonary disease (COPD), a recent study shows.