Most Read Articles
Roshini Claire Anthony, 5 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

10 Aug 2018

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 6 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.

Antirheumatic drugs may reduce humoral response to vaccination

07 Jun 2018
The pharmacist’s role in promoting immunisation programmes

Pneumococcal responses with methotrexate (MTX) exposure show that antirheumatic drugs may limit humoral responses to vaccination, but such treatment remains safe and must not prevent immunization against vaccine-preventable disease, according to the results of a systematic review and meta-analysis.

“Vaccination should be considered in all patients with rheumatoid arthritis (RA) and encouraged as part of routine care,” the authors said.

The meta-analysis included nine studies (seven studies investigating antirheumatic drug exposures and influenza humoral response and two studies investigating pneumococcal vaccine response).

There were sustained responses of the influenza vaccine to all subunit strains (H1N1, H3N2, B strain) with MTX and tumour necrosis factor inhibitor (TNFi) drug exposure. However, pneumococcal vaccine response to 6B and 23F was reduced with MTX but not TNFi drug exposure (risk ratio [RR], 0.42; 95 percent CI, 0.28–0.63 vs RR, 0.98; 0.58–1.67).

Available data were limited to draw any firm conclusions regarding this finding, the authors said.

In addition, combination of MTX and tocilizumab or tofacitinib correlated with reduced pneumococcal and influenza vaccine responses.

A systematic review and meta-analysis was conducted comparing the humoral response to influenza (pandemic and seasonal trivalent subunit vaccines) and pneumococcal (23-valent pneumococcal polysaccharide vaccine, 7- and 13-valent pneumococcal conjugated vaccines) vaccination in adult patients with RA treated with antirheumatic drugs. Vaccine immunogenicity was evaluated by seroprotection rates measured 3–6 weeks postimmunization.

“Vaccination is a key strategy to reduce infection risk in patients with RA and is advocated in internationally recognized rheumatology society guidelines,” the authors said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Rheumatology digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 5 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

10 Aug 2018

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 6 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.