Most Read Articles
Kavitha G. Shekar, 31 Mar 2016
The prevalence of psychiatric conditions in young transgender women (16 to 29 years) was found to be as high as 41 percent, said researchers. Substance dependence was also high.
Dr. Joseph Delano Fule Robles, 30 Jan 2019

Five subtypes of insomnia disorder were identified by investigators from The Netherlands, addressing an unmet need to reduce the heterogeneity of insomnia disorder.

Jackey Suen, 06 Apr 2016
Children with attention deficit hyperactivity disorder (ADHD) and their parents find a 6-month multiple family group therapy (MFGT) effective, a study by the Chinese University of Hong Kong (CUHK) has shown.
Pearl Toh, 04 Apr 2016
Elderly people (mean age 71 years) who exercised less showed a faster decline in learning and thinking abilities, according to the NOMAS* study.

Antipsychotic treatment maintenance reduces risk of relapse in FEP patients

13 Jul 2018

Patients with first-episode psychosis (FEP) may benefit from continuing their antipsychotic treatment, with a recent study showing that treatment maintenance protects against relapse risk, whereas discontinuation for 2 months increases the risk.

Researchers performed a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing FEP relapse rates between antipsychotic treatment discontinuation and maintenance groups at 1, 2, 3, 6, 9, 12 (primary), and 18–24 months.

A total of 10 RCTs, involving 776 FEP patients with a mean study duration of 18.6 months, were included. Of these, four RCTs had the antipsychotics discontinued abruptly. The remaining six RCTs had treatment ceased after tapering off gradually over several months.

Relapses occurred with significantly greater frequency in the discontinuation group than in the maintenance group. This was true at all time points except at 1 month (2 months: risk ratio [RR], 0.49; 3 months: RR, 0.46; 6 months: RR, 0.55; 9 months: RR, 0.48; 12 months: RR, 0.47; 18–24 months: RR, 0.57).

However, maintenance treatment was associated with a nonsignificant increase in the risk of discontinuation due to adverse events (RR, 2.61).

Although it appears that maintaining antipsychotic treatment is beneficial for preventing relapses for at least 2 years in remitted/stable FEP patients, it remains unclear whether this would be the case for longer than 2 years, researchers said.

There are currently no clinical measures or biomarkers that may facilitate identification of remitted/stable FEP patients who are not at risk of relapse after discontinuation of their antipsychotic treatment, they added. More work is needed to establish these predictive biomarkers to aid in decision-making and a personalized medicine approach.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Psychiatry - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Kavitha G. Shekar, 31 Mar 2016
The prevalence of psychiatric conditions in young transgender women (16 to 29 years) was found to be as high as 41 percent, said researchers. Substance dependence was also high.
Dr. Joseph Delano Fule Robles, 30 Jan 2019

Five subtypes of insomnia disorder were identified by investigators from The Netherlands, addressing an unmet need to reduce the heterogeneity of insomnia disorder.

Jackey Suen, 06 Apr 2016
Children with attention deficit hyperactivity disorder (ADHD) and their parents find a 6-month multiple family group therapy (MFGT) effective, a study by the Chinese University of Hong Kong (CUHK) has shown.
Pearl Toh, 04 Apr 2016
Elderly people (mean age 71 years) who exercised less showed a faster decline in learning and thinking abilities, according to the NOMAS* study.