Most Read Articles
5 days ago
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 2 days ago
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from a large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
5 days ago
Treatment with metformin may improve whole-body and peripheral insulin resistance (IR) in youth who are overweight/obese with type 1 diabetes (T1D), according to a study.
2 days ago
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.

Antinuclear antibody negativity ups risk of malignancy in adult-onset dermatomyositis

08 May 2019

Antinuclear antibody (ANA) negativity appears to increase the likelihood of developing malignancy in patients with adult-onset dermatomyositis (DM) within 3 years of diagnosis of their DM, according to a recent study.

“Particularly close follow-up and frequent malignancy screening may be warranted in ANA individuals with DM,” the authors said.

This retrospective cohort study compared the incidence of amyopathic disease, risk of malignancy and clinical findings in ANA+ and ANA patients with adult-onset DM, determined by enzyme-linked immunosorbent assay.

A total of 231 patients were included, of whom 140 (61 percent) were ANA+ and 91 (39 percent) were ANA. The frequency of dysphagia (15 percent vs 26 percent; p=0.033) and heliotrope rash (38 percent vs 53 percent; p=0.026) was lower in ANA+ patients compared with ANA patients.

Overall, malignancy developed in 54 patients (23 percent) within 3 years of diagnosis of DM. More ANA patients developed malignancy than ANA+ patients (43 percent vs 11 percent; p<0.001).

In multivariable analysis, ANA positivity was strongly associated with a lower likelihood of malignancy (odds ratio [OR], 0.16; p<0.001). In contrast, there was no association found between ANA positivity and amyopathic disease (OR, 0.94; p=0.87).

This study was limited by its retrospective nature, according to the authors.

An earlier study by Fardet and colleagues found the following factors to be independently associated with an underlying malignancy in DM patients: age at diagnosis >52 years (hazard ratio [HR], 7.24; 95 percent CI, 2.35–22.31), a rapid onset of skin and/or muscular symptoms (HR, 3.11; 1.07–9.02), presence of skin necrosis (HR, 3.84; 1.00–14.85) or periungual erythema (HR, 3.93; 1.16–13.24) and a low baseline level of complement factor C4 (HR, 2.74; 1.11–6.75). [Medicine (Baltimore) 2009;88:91-97]

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
5 days ago
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 2 days ago
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from a large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
5 days ago
Treatment with metformin may improve whole-body and peripheral insulin resistance (IR) in youth who are overweight/obese with type 1 diabetes (T1D), according to a study.
2 days ago
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.