Most Read Articles
01 Nov 2013

Joint stiffness is defined as discomfort after a period of inactivity. It is associated with reduced or loss of range of motion in a joint.

01 Aug 2016
Etoricoxib exhibits a central mode of action and enhances pain and function in patients with painful knew osteoarthritis (OA), as presented in a randomised, double-blind, placebo-controlled, two-way crossover, four-week treatment study.
Stephen Padilla, 25 Nov 2016
The addition of supervised physiotherapy to usual care does not provide clinically important improvement in the management of simple ankle sprains in a general population of patients seeking hospital-based acute care, according to results of a recent randomized controlled trial.
24 Jul 2017
The toxic side-effects of chemotherapy appear to be induced by cell-free chromatin (cfCh) fragments released from dying cells, triggering DNA damage, apoptosis and inflammation in healthy cells, thereby exaggerating or amplifying the toxic effects caused by the drugs themselves, according to a study.

Antimalarial exposure during pregnancy protects against cardiac neonatal lupus

11 Jul 2017

Exposure to antimalarial drugs throughout pregnancy may lower the likelihood of developing cardiac but not noncardiac neonatal lupus, according to a single-centre retrospective cohort study.

Researchers examined 268 pregnancies in women with a connective tissue disease (CTD) and positive anti-Ro and/or anti-La antibodies. Exposure to antimalarials was defined as hydroxychloroquine (HCQ) or chloroquine throughout pregnancy. Outcomes of interest were cardiac and noncardiac neonatal lupus.

Of the pregnancies, 73 were exposed to antimalarials. Neonatal lupus occurred in 99 children, whereas 117 were unaffected. The remaining 52 children, while not having developed cardiac neonatal lupus, could not be categorized as unaffected as their full noncardiac neonatal lupus status was unknown.

Logistic regression analysis found a protective association between antimalarial exposure and cardiac neonatal lupus, although the result was not statistically significant (odds ratio [OR], 0.21; p=0.07). On Bayesian analysis, the probability of achieving protection (OR <1.0) against cardiac neonatal lupus was significant (98.7 percent). On the other hand, the effect of antimalarials on noncardiac neonatal lupus was not found to be significant (OR, 0.78; p=0.21).

Antimalarials, particularly hydroxychloroquine, have widely recognized benefits beyond the control of disease activity among systemic lupus erythematosus patients. Recent data support the role of prolonged hydroxychloroquine treatment in the prevention of damage accrual, which may extend to increased survival. Furthermore, the drug has been proven to be safe to the foetus during pregnancy and to newborns, as it does not induce retinal toxicity, ototoxicity, adverse effects on infant growth or neurodevelopment. [J Rheumatol 2005;32:1709–1712; Lupus 2004;13:688–689]

Antimalarial drugs, particularly HCQ, have been shown to have immunomodulatory, hypoglycaemic, lipid-lowering and antithrombotic effects. Given the benefits and the safety profile of the drug, a study has recommended prescription of HCQ to all SLE patients, with the drug dosed to the ideal body weight rather than to the actual weight. Timely ophthalmological monitoring should also be performed to prevent retinal toxicity. [Future Rheumatol 2006;1:225–233]

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Most Read Articles
01 Nov 2013

Joint stiffness is defined as discomfort after a period of inactivity. It is associated with reduced or loss of range of motion in a joint.

01 Aug 2016
Etoricoxib exhibits a central mode of action and enhances pain and function in patients with painful knew osteoarthritis (OA), as presented in a randomised, double-blind, placebo-controlled, two-way crossover, four-week treatment study.
Stephen Padilla, 25 Nov 2016
The addition of supervised physiotherapy to usual care does not provide clinically important improvement in the management of simple ankle sprains in a general population of patients seeking hospital-based acute care, according to results of a recent randomized controlled trial.
24 Jul 2017
The toxic side-effects of chemotherapy appear to be induced by cell-free chromatin (cfCh) fragments released from dying cells, triggering DNA damage, apoptosis and inflammation in healthy cells, thereby exaggerating or amplifying the toxic effects caused by the drugs themselves, according to a study.