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Tristan Manalac, 6 days ago
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Antihistamines do not improve atopic dermatitis symptoms

21 Jul 2018
Antihistamines: What they didn’t teach us in school

Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.

To evaluate the use of sedating and nonsedating antihistamines for AD in 2003–2012, the authors used data on physician visits in 2013–2012 from the National Ambulatory Medical Care Survey and identified sedating and nonsedating antihistamine use at visits for AD.

A total of 990,000 annual visits for AD were reported. A significant proportion of visits across physician specialties (16–44 percent) reported a prescription of antihistamines for AD. Dermatologists and paediatricians were the main prescribers of sedating antihistamines (58–70 percent), while most family or general practitioners, internists, and other specialties used nonsedating antihistamines for AD (55–100 percent).

Interestingly, a 2003 study has shown that dermatologists warrant further evidence in terms of the efficacy of antihistamines and their mechanism of action in the treatment of AD to enhance patient care. [J Cutan Med Surg 2003;7:467-473]

The present study was limited by the accuracy of AD diagnosis and medication recording, according to the authors.

“Antihistamines are often used to treat pruritus associated with AD despite lack of evidence for their efficacy,” they said. “The American Academy of Dermatology does not recommend the general use of antihistamines in the management of AD, although the value of short-term sedating antihistamine use for insomnia secondary to itch is recognized.”

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Most Read Articles
Tristan Manalac, 6 days ago
Left ventricular assist devices (LVADs) can reverse pulmonary hypertension secondary to left heart disease regardless of baseline pulmonary vascular resistance, according to a new study.
Yesterday
It appears that long-term consumption of fish and omega-3 fatty acid does not influence the risk of incident hypertension in middle-aged and older men, suggests a US study.
11 May 2019
Acute kidney injury (AKI) commonly occurs within a year after cancer diagnosis in paediatric patients and is tied to long-term deteriorations in renal function, a recent study has found.
11 May 2019
Women practicing exclusive breastfeeding for 6 months achieve greater postpartum weight loss compared with those exclusively breastfeeding for a shorter duration, according to data from the MILK* study.