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Elvira Manzano, Yesterday
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Jairia Dela Cruz, Yesterday
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Jairia Dela Cruz, 16 Sep 2020
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Pearl Toh, 21 Sep 2020
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Antihistamines do not improve atopic dermatitis symptoms

21 Jul 2018
Antihistamines: What they didn’t teach us in school

Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.

To evaluate the use of sedating and nonsedating antihistamines for AD in 2003–2012, the authors used data on physician visits in 2013–2012 from the National Ambulatory Medical Care Survey and identified sedating and nonsedating antihistamine use at visits for AD.

A total of 990,000 annual visits for AD were reported. A significant proportion of visits across physician specialties (16–44 percent) reported a prescription of antihistamines for AD. Dermatologists and paediatricians were the main prescribers of sedating antihistamines (58–70 percent), while most family or general practitioners, internists, and other specialties used nonsedating antihistamines for AD (55–100 percent).

Interestingly, a 2003 study has shown that dermatologists warrant further evidence in terms of the efficacy of antihistamines and their mechanism of action in the treatment of AD to enhance patient care. [J Cutan Med Surg 2003;7:467-473]

The present study was limited by the accuracy of AD diagnosis and medication recording, according to the authors.

“Antihistamines are often used to treat pruritus associated with AD despite lack of evidence for their efficacy,” they said. “The American Academy of Dermatology does not recommend the general use of antihistamines in the management of AD, although the value of short-term sedating antihistamine use for insomnia secondary to itch is recognized.”

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Most Read Articles
Elvira Manzano, Yesterday
Monthly injections of the PCSK9* monoclonal antibody evolocumab effectively reduced plasma LDL-cholesterol (LDL-C), often referred to as the bad cholesterol, in teenagers with heterozygous familial hypercholesterolaemia (HeFH) already taking statins, with or without ezetimibe, the HAUSER-RCT has shown.
Jairia Dela Cruz, Yesterday
For individual with type 2 diabetes, losing weight is everything when it comes to improving the metabolic function, and it matters little whether this is achieved by dieting or undergoing bariatric surgery, according to a small study.
Jairia Dela Cruz, 16 Sep 2020
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Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.