Most Read Articles
01 Oct 2015
BLACKMORES ESSENTIAL LIVO – Phosphatidylcholine, Zinc and Chromium Capsules
13 Dec 2016
Any abnormal decrease in a person’s usual bowel movement frequency and/or pain during stool passage is termed as Constipation.
Roshini Claire Anthony, 6 days ago

The incidence of cardiovascular events in the first year following a primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) is comparable between patients given prasugrel and ticagrelor post-surgery, according to results of the PRAGUE-18* trial presented at AHA 2017.

Roshini Claire Anthony, 08 Nov 2017

The presence of vitreous haze, snow banking, and choroidal involvement is associated with an increased risk of antitubercular treatment failure in patients with tubercular (TB) uveitis, according to research by the COTS-1* Study Group.

Antiepileptic drugs, systemic antibacterials up risk of adverse drug reactions

15 Aug 2017

Use of antiepileptic drugs, a history of adverse drug reactions (ADR) and use of meglumine are all risk factors for ADR in paediatric patients, a new cohort study has shown.

In a cohort of 173 children, with 208 admission and 2,167 prescription data, 109 adverse drug events (ADE) were reported in 52 children. Of these, 12.8 percent (n=14) were classified as definite ADR, 47.7 percent (n=52) were probable, 29.4 percent (n=32) were possible and 10.1 percent (n=11) were classified as doubtful.

An analysis of all definite and probable ADRs showed that gastrointestinal disorders were the most common ADR, comprising 28.8 percent (n=19) of all total cases. This was followed by ADR related to systemic antibacterials (22.7 percent) and general anaesthesia (15.2 percent). The overall incidence rates of definite and probable ADRs were 22.1 and 21.9 percent, respectively.

Multivariate analysis showed that a prior history of ADR (hazard ratio [HR], 2.44; 95 percent CI, 1.19 to 5.00; p=0.01) and an administration of meglumine antimonite (HR, 4.98; 1.21 to 20.54; p=0.02) were significant risk factors for ADRs.

Antiepileptic drugs (HR, 3.84; 1.40 to 10.56; p=0.009) and antibacterials for systemic use (HR, 2.75; 1.08 to 6.98; p=0.03) were also significant risk factors for ADR.

Study participants were recruited from a general paediatric ward of a public teaching hospital in Northeastern Brazil. Only those treated for at least 48 hours were included. Those that were not administered drugs during hospital stay were excluded.

The principal outcome of the study was the occurrence of ADRs. The Naranjo and Hartwig algorithms were used to evaluate causality and severity of ADEs, respectively.

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Most Read Articles
01 Oct 2015
BLACKMORES ESSENTIAL LIVO – Phosphatidylcholine, Zinc and Chromium Capsules
13 Dec 2016
Any abnormal decrease in a person’s usual bowel movement frequency and/or pain during stool passage is termed as Constipation.
Roshini Claire Anthony, 6 days ago

The incidence of cardiovascular events in the first year following a primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) is comparable between patients given prasugrel and ticagrelor post-surgery, according to results of the PRAGUE-18* trial presented at AHA 2017.

Roshini Claire Anthony, 08 Nov 2017

The presence of vitreous haze, snow banking, and choroidal involvement is associated with an increased risk of antitubercular treatment failure in patients with tubercular (TB) uveitis, according to research by the COTS-1* Study Group.