Most Read Articles
Elaine Soliven, 20 May 2020
Early treatment with a triple antiviral combination of lopinavir-ritonavir, ribavirin, and interferon beta-1b significantly shortens the duration of virus shedding and reduces symptoms in patients with mild-to-moderate COVID-19 compared with lopinavir-ritonavir only, according to a recent study.
Pearl Toh, 26 Sep 2019
The Singapore Health Sciences Authority (HSA) has recalled eight brands of ranitidine products containing trace amounts of the nitrosamine impurity NDMA*, which is a potential human carcinogen.
Roshini Claire Anthony, 27 May 2020

The use of a vaginal cleansing intervention prior to Caesarean delivery reduced the incidence of surgical site infections (SSIs), according to a study presented at ACOG 2020. However, the addition of intravenous (IV) azithromycin prophylaxis had no added impact on SSI rates. 

Pank Jit Sin, 14 Apr 2020
With the movement control order (MCO) in full gear, most conferences and meetings are being postponed or cancelled. Some have taken to having conferences and meetings in a virtual setting, such as the recently ended American College of Cardiology/World Congress of Cardiology (ACC.20/WCC) conference. MIMS and the Asian Young Pharmacist Group (AYPG) took this opportunity to engage with pharmacists in the form of a Zoom meeting. 

Antidepressants up fracture risk in older adults

21 Apr 2020

Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), appear to increase the risk of fractures in older adults, a recent study has shown.

Researchers conducted a retrospective cohort study on elderly antidepressant users from five jurisdictions across the US (n=17,359), Canada (Montreal: n=23,422; Quebec: n=4,448), UK (n=24,858) and Taiwan (n=24,225). The main outcome measure was the risk of sustaining fractures.

The choice of antidepressant varied across locations. Amitriptyline, for example, was the most common prescription in the UK, while Taiwanese participants were frequently on imipramine. SSRIs dominated the US prescriptions, with rates ranging from 19.7 percent to 29.0 percent.

The rates of fractures developed over the follow-up period were similar across all jurisdictions, except for Taiwan, where the rate was much higher. This was driven by an excess in the incidence of spine-skill fractures.

The use of antidepressants increased the risk of fractures by 7 percent in Montreal and by 10 percent in the UK. This effect was strongest in the US, where antidepressant use correlated with a 31 percent jump in the likelihood of sustaining a fracture. Dosing, which was systematically higher in the US, could account for this discrepancy. When doses were used for the model, the excess risk estimate was at 9 percent.

Specifically, SSRIs increased the risk of fractures by 17 percent to 31 percent. Citalopram, the most commonly prescribed SSRI, was associated with 23 percent to 43 percent excess risk.

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Most Read Articles
Elaine Soliven, 20 May 2020
Early treatment with a triple antiviral combination of lopinavir-ritonavir, ribavirin, and interferon beta-1b significantly shortens the duration of virus shedding and reduces symptoms in patients with mild-to-moderate COVID-19 compared with lopinavir-ritonavir only, according to a recent study.
Pearl Toh, 26 Sep 2019
The Singapore Health Sciences Authority (HSA) has recalled eight brands of ranitidine products containing trace amounts of the nitrosamine impurity NDMA*, which is a potential human carcinogen.
Roshini Claire Anthony, 27 May 2020

The use of a vaginal cleansing intervention prior to Caesarean delivery reduced the incidence of surgical site infections (SSIs), according to a study presented at ACOG 2020. However, the addition of intravenous (IV) azithromycin prophylaxis had no added impact on SSI rates. 

Pank Jit Sin, 14 Apr 2020
With the movement control order (MCO) in full gear, most conferences and meetings are being postponed or cancelled. Some have taken to having conferences and meetings in a virtual setting, such as the recently ended American College of Cardiology/World Congress of Cardiology (ACC.20/WCC) conference. MIMS and the Asian Young Pharmacist Group (AYPG) took this opportunity to engage with pharmacists in the form of a Zoom meeting.