Most Read Articles
Roshini Claire Anthony, 16 Oct 2017

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
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Antidepressants show potential for managing depression in schizophrenia

01 Oct 2017

Antidepressants may be effective for treating depression in patients with schizophrenia, according to a meta-analysis that underscores qualifying conclusions based on the small number of low- or moderate-quality studies.

Researchers performed a meta-analysis of 26 trials that included adult patients with schizophrenia or related psychosis who had a depressive episode. Based on the Cochrane risk bias tool, the quality of the studies was moderate to low.

Pooled data indicated that antidepressants (eg, selective serotonin reuptake inhibitors [SSRIs], tricyclic antidepressants) had a favourable effect on the risk of depression compared with placebo, with a small risk difference –0.19 (95 percent CI, –0.27 to –0.11) and corresponding number needed to treat of 5 (4 to 9).

The effect size was larger in studies using tools specifically designed to assess depression in schizophrenia. On sensitivity analysis, however, standardized mean difference of all antidepressants, as well as any individual antidepressant class, showed no statistically significant improvement in depression score at endpoint.

In light of the methodological limitations of current published findings, researchers recommend that future large-scale trials should prioritize the appropriate measurement of depressive symptoms in schizophrenia, include reporting of adverse outcomes, and use an adequate method of randomization, allocation, concealment and specific depression inclusion criteria.   

Depression contributes to the extensive burden of schizophrenia, and its management is crucial to recovery. Improvement in depression status may result in better long-term functional outcomes, including medication adherence, service utilization, substance misuse, suicide attempts and quality of life. [Schizophr Res 2016;172:23–28]

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Most Read Articles
Roshini Claire Anthony, 16 Oct 2017

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.