Most Read Articles
Roshini Claire Anthony, 04 Apr 2019

In addition to an intensive weight loss programme, the use of continuous positive airway pressure (CPAP) could improve absolute weight loss in individuals with obesity and obstructive sleep apnoea (OSA), according to a study presented at ENDO 2019.

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Anticoagulation safely reduces stroke risk in cirrhotics with AF

5 days ago

Anticoagulation treatment in patients with atrial fibrillation and cirrhosis reduces the risk of stroke without increasing the likelihood of bleeding, according to a recent meta-analysis.

Researchers reviewed databases of Embase, Medline and Cochrane for studies focused on cirrhotic patients taking oral anticoagulants for AF. Only those that reported stroke and bleeding outcomes were eligible for inclusion.

A total of seven cohort studies were eventually included in the meta-analysis, yielding a cumulative sample size of 19,798 patients. Participants were followed up for a mean of 11 years, during which time the use of anticoagulation ranged from 8.3–53.9 percent.

Pooled analysis revealed that anticoagulation significantly reduced the risk of stroke in participants (hazard ratio [HR], 0.58; 95 percent CI, 0.35–0.96). On the other hand, there was no associated significant increase in the risk of bleeding (HR, 1.45; 0.96–2.17).

Notably, when compared with warfarin, researchers found that the use of direct oral anticoagulants was associated with a significantly lower risk of bleeding among cirrhotic patients with AF (odds ratio, 1.93; 1.001–3.70).

In terms of study quality, funnel plots and Egger’s regression asymmetry analysis revealed no significant publication bias, though there was some variation in how cirrhosis was defined. While some referred to health database systems, other studies employed clinical diagnoses, lab tests, imaging techniques and markers.

“Our study suggests that anticoagulation treatment in cirrhotic patients with AF may be beneficial. Hence, rather than refraining cirrhotic patients from systemic anticoagulation due to bleeding diathesis concerns, patients should be prescribed this type of therapy with close clinical and laboratory surveillance,” said researchers.

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Most Read Articles
Roshini Claire Anthony, 04 Apr 2019

In addition to an intensive weight loss programme, the use of continuous positive airway pressure (CPAP) could improve absolute weight loss in individuals with obesity and obstructive sleep apnoea (OSA), according to a study presented at ENDO 2019.

4 days ago
The ketogenic and Modified Atkin’s diets are effective treatments for children with refractory epilepsy of genetic aetiology, a new study suggests.
5 days ago
Extremely premature neonates who have been exposed to pre-eclampsia in utero are at high risk of developing severe respiratory distress syndrome and severe bronchopulmonary dysplasia, according to a study.
Pearl Toh, 3 days ago
A contraceptive vaginal system (Annovera) releasing a combination of segesterone acetate and ethinyl estradiol (SA/EE) effectively inhibits ovulation up to a year even at low systemic levels of SA, reports a review study presented at ENDO 2019.