Most Read Articles
Pearl Toh, 3 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Elvira Manzano, 3 days ago
An investigational transdermal amphetamine patch worn for 9 hours on the hip appeared effective in paediatric patients with attention deficit-hyperactivity disorder (ADHD) in a phase II, two-part trial.
Tristan Manalac, 5 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.

Antibody seroprevalence low in cirrhotic patients with mild COVID-19

4 days ago

In liver cirrhosis patients with an asymptomatic or mildly symptomatic case of the novel coronavirus disease (COVID-19), the seroprevalence of antibodies against SARS-CoV-2 seems to be low, a recent study has found.

The study included 202 cirrhotic patients (median age 70.9 years, 64.9 percent men). While all were positive for COVID-19, only 22.3 percent (n=45) were symptomatic. The most common symptoms were fever and cough (11.9 percent each) and diarrhoea (4.5 percent).

Only three participants tested positive for antibodies against SARS-CoV-2, yielding an overall seroprevalence rate of 1.5 percent. When considering only the asymptomatic patients, the corresponding seroprevalence rose to 1.9 percent.

Notably, all three patients showed no symptoms of COVID-19 but presented with compensated liver cirrhosis. Work arrangements, visits from relatives, and medical visits were the suspected sources of the infection.

During the observation period, 24 participants experienced liver-related events, the most frequent of which was hepatic encephalopathy (37.5 percent). This was followed by ascites (33.3 percent) and gastrointestinal bleeding (16.7 percent). One patient developed hepatocellular carcinoma. Interestingly, such events occurred more commonly among those without vs with postponed hepatology visit.

“To our knowledge, this is the first report on the prevalence of asymptomatic or mildly symptomatic SARS-CoV-2 infection in patients with liver cirrhosis,” the researchers said. “[O]ur study reports a prevalence of positive SARS-CoV-2 antibodies as high as 1.5 percent in a sample of consecutive asymptomatic or mildly symptomatic patients with liver cirrhosis.”

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Most Read Articles
Pearl Toh, 3 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Elvira Manzano, 3 days ago
An investigational transdermal amphetamine patch worn for 9 hours on the hip appeared effective in paediatric patients with attention deficit-hyperactivity disorder (ADHD) in a phase II, two-part trial.
Tristan Manalac, 5 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.