Most Read Articles
Radha Chitale, 25 Apr 2016
Two kinds of oral bacteria were associated with an increased risk of pancreatic cancer, according to research presented at the 2016 meeting of the American Association for Cancer Research (AACR), held recently in New Orleans, Louisiana, US.
24 Dec 2017
Patients with fluoroquinolone-resistant rectal vault flora appear to have higher odds of developing infectious complications following transrectal ultrasound-guided prostate needle biopsy despite targeted prophylaxis, a study has found.
31 Mar 2016
Lymphoid-resistant commensal bacteria (LRCs) colonize the interstitial lymphoid tissues of healthy mammals.
Pearl Toh, 03 Nov 2017
Increasing daily water intake by 1.5 L can half the risk of recurrent acute uncomplicated cystitis (rAUC) in women, suggests a study presented at the recent Infectious Disease Week (IDWeek) in San Diego, California, US.

Antibiotics eradicate S. aureus colonization, prevent SSTI recurrence in children

13 Oct 2017

Use of systemic antibiotics, in conjunction with performance of incision and drainage, in the management of paediatric acute skin and soft tissue infection (SSTI) appears to reduce Staphylococcus aureus colonization and the likelihood of infection recurrence, a prospective study has found.

Researchers looked at a cohort of 383 children (median age 3 years; 56 percent female) with S. aureus SSTI for which an incision and drainage procedure was performed. Swab samples from the children revealed S. aureus colonization in the anterior nares, axillae or inguinal folds.

Guideline-recommended antibiotics were empirically prescribed to 355 (93 percent) patients, with 81 receiving more than one antibiotic class. Most received clindamycin (n=220) or trimethoprim-sulfamethoxazole (n=199), while the others were given vancomycin (n=19) beta-lactams (n=12). The remaining patients in the cohort were not prescribed systemic antibiotics.

Repeat colonization sampling was performed within 3 months (median 38 days) in 357 patients, and incidence of recurrent infection was ascertained for up to 1 year.

Results showed that children prescribed guideline-recommended empiric antibiotics had reduced likelihood of remaining colonized at follow-up sampling (adjusted hazard ratio [aHR] 0.49; 95 percent CI, 0.30 to 0.79) and of having recurrent SSTI (aHR, 0.57; 0.34, 0.94) compared with those who did not receive antibiotics for their SSTI.

Of note, remaining colonized at repeat sampling was associated with a more than twofold risk of infection recurrence over 12 months (aHR, 2.37, 95% CI 1.69, 3.31).

Clindamycin was particularly superior to trimethoprim-sulfamethoxazole in eradicating S. aureus colonization (44 vs 57 percent remained colonized; p=0.03) and preventing recurrent SSTI (31 vs 47 percent had recurrence; p=0.008).

The current findings establish the benefit of systemic antibiotics beyond the resolution of acute SSTI, researchers claimed, adding that they should inform continuing conversations about optimal clinical management of SSTI in the contemporary era.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Infectious Diseases - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Radha Chitale, 25 Apr 2016
Two kinds of oral bacteria were associated with an increased risk of pancreatic cancer, according to research presented at the 2016 meeting of the American Association for Cancer Research (AACR), held recently in New Orleans, Louisiana, US.
24 Dec 2017
Patients with fluoroquinolone-resistant rectal vault flora appear to have higher odds of developing infectious complications following transrectal ultrasound-guided prostate needle biopsy despite targeted prophylaxis, a study has found.
31 Mar 2016
Lymphoid-resistant commensal bacteria (LRCs) colonize the interstitial lymphoid tissues of healthy mammals.
Pearl Toh, 03 Nov 2017
Increasing daily water intake by 1.5 L can half the risk of recurrent acute uncomplicated cystitis (rAUC) in women, suggests a study presented at the recent Infectious Disease Week (IDWeek) in San Diego, California, US.